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Evidence-scored research index

The latest scientific discoveries, scored.

The most significant recent scientific breakthroughs and discoveries in research and technology, each graded 0 to 100 across evidence, impact, and novelty. Every score decomposes to its primary sources.

This week: 40 new papers scored, led by Cross-species multiomic atlas of the primate basal ganglia at 74. See the week's ranking

How every score is computed

integrity × recency × (0.25 Evidence + 0.25 Impact + 0.50 Novelty)

Every weight and source is public. Read the method

The Frontier Index

Ranked by live Frontier Score. Search, filter, or sort by any pillar.How scoring works

390 breakthroughs
Sort
Since
#
01
Biomedicine & Health· Notable
Tracing the spread of Germanic languages using ancient genomics

Ancient DNA suggests Germanic may have reached Scandinavia some 800 years later than assumed

E 93I 59N 82
78
93
59
82
Early signalOct 28, 2026
02
Physics· Notable
Multimodal X-ray imaging reveals hierarchical fibre mechanics

A new X-ray method maps how collagen fibrils and fibres share load inside intact rat spinal discs

E 91I 47N 85
77
91
47
85
Early signalNov 4, 2026
03
Biomedicine & Health· Notable
Clostridium perfringens Delta toxin targets CD9 to drive NEC and brain injury
E 92I 37N 91
77
92
37
91
Early signalOct 28, 2026
04
Biomedicine & Health· Notable
Population-scale single-nucleus multi-omic profiling of skeletal muscle reveals extensive context-specific genetic regulation

Single-nucleus maps of 287 muscle biopsies match almost 3,500 trait signals to regulatory variants

E 93I 57N 77
75
93
57
77
Early signalOct 28, 2026
05
Biomedicine & Health· Notable
Efficient and accurate mixed model association tool for single-cell eQTL analysis

In 1.2 million immune cells, a single-cell model found 48.8% more eGenes than a standard pooled pipeline

E 90I 53N 78
74
90
53
78
Early signalNov 6, 2026
06
Biomedicine & Health· Notable
Cross-species multiomic atlas of the primate basal ganglia
E 91I 76N 67
74
91
76
67
Early signalNov 1, 2026
07
Biomedicine & Health· Notable
Rare and common genetic variants shape single-cell immune gene expression
E 94I 63N 73
74
94
63
73
Early signalOct 28, 2026
08
AI & Computing· Notable
An open vision-language model for diverse medical applications

Open medical AI models built on Gemma 3 beat their general-purpose base across medical images and text

E 91I 96N 64
74
91
96
64
Early signalOct 1, 2026
09
Biomedicine & Health· Major
MemBrain v2: an end-to-end tool for the analysis of membranes in cryo-electron tomography
E 88I 93N 71
74
88
93
71
Firming upSep 8, 2026
10
AI & Computing· Notable
Generating interesting scientific ideas using knowledge graphs and LLMs: Evaluations with 100 research group leaders

Asked to rate over 4,400 AI-generated ideas, 100-plus group leaders called a quarter interesting

E 88I 63N 72
73
88
63
72
Early signalNov 9, 2026
11
Biomedicine & Health· Notable
Eukaryotes’ closest relatives are internally simple syntrophic peptidotrophic archaea
E 92I 61N 74
73
92
61
74
Early signalOct 28, 2026
12
AI & Computing· Notable
Reimagining research papers as interactive and reliable AI agents
E 94I 68N 76
73
94
68
76
Early signalSep 16, 2026
13
AI & Computing· Notable
Intrinsically motivated humans and agents in open-world exploration

Children, adults and AI agents in a Minecraft-like game seem to seek novelty first, then control

E 91I 57N 71
71
91
57
71
Early signalNov 4, 2026
14
Biomedicine & Health· Notable
Tandem repeat variation shapes immune cell type-specific gene expression

Repeated stretches of DNA shape gene activity immune cell type by cell type, across 1,925 people

E 94I 54N 72
71
94
54
72
Early signalOct 28, 2026
15
AI & Computing· Notable
Sequential diagnosis with language models

A language-model system simulating a panel of physicians correctly diagnosed 83.2% of NEJM case-conference cases in a benchmark, against 36.1% for generalist physicians.

E 93I 81N 59
71
93
81
59
Early signalOct 22, 2026
16
Biomedicine & Health· Notable
Comparative analysis of mitochondrial proteomes across the tree of life
E 94I 57N 75
71
94
57
75
Early signalOct 1, 2026
17
Biomedicine & Health· Notable
Robust fine-mapping in the presence of linkage disequilibrium mismatch

A fine-mapping method holds up better than existing tools when the reference panel does not match the study

E 91I 51N 70
70
91
51
70
Early signalNov 6, 2026
18
Biomedicine & Health· Notable
A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity

A map of 12 glioblastomas finds their cells on one path, from development-like states to injury and low oxygen

E 94I 48N 70
70
94
48
70
Early signalNov 4, 2026
19
Neuroscience· Notable
Aggression experience and observation drive shared behavioural and neural changes

Mice that only watched fights later fought more like experienced fighters, with shared brain changes

E 93I 45N 72
70
93
45
72
Early signalNov 4, 2026
20
Neuroscience· Notable
An astrocyte-microglia MFG-E8 axis promotes synapse engulfment in early amyloid pathology

In mice, astrocytes in an early bulbous state release a signal microglia need to eat the synapses beside them

E 90I 48N 73
70
90
48
73
Early signalNov 1, 2026
21
Biomedicine & Health· Notable
Pervasive patterns in bird songs resemble those in human speech and song and are independent of vocal learning
E 94I 49N 70
70
94
49
70
Early signalOct 29, 2026
22
Biomedicine & Health· Notable
MCT1-dependent mitochondrial lactate import sustains cardiac metabolism
E 96I 49N 72
70
96
49
72
Early signalOct 28, 2026
23
Neuroscience· Notable
Connectome simulations identify a central pattern generator for fly walking
E 96I 62N 65
70
96
62
65
Early signalOct 28, 2026
24
Biomedicine & Health· Notable
Genetic variants shape single-cell chromatin accessibility and disease risk
E 94I 50N 71
70
94
50
71
Early signalOct 28, 2026
25
Biomedicine & Health· Notable
Steroid hormones produced by coral-associated Endozoicomonas influence coral immune response during thermal stress

Coral bacteria make testosterone and progesterone, and giving corals either one shifts their immune genes

E 91I 44N 77
70
91
44
77
Early signalOct 22, 2026
26
Neuroscience· Notable
Functional architecture of the human insula
E 94I 50N 74
70
94
50
74
Early signalOct 21, 2026
27
Biomedicine & Health· Notable
De novo design of cysteine proteases
E 91I 64N 70
70
91
64
70
Early signalOct 14, 2026
28
Other frontiers· Notable
Educational intervention can rewire village social networks
E 96I 39N 78
70
96
39
78
Early signalOct 14, 2026
29
Biomedicine & Health· Notable
Prehistoric global migration of vanishing gut microbes with humans
E 94I 50N 75
70
94
50
75
Early signalOct 7, 2026
30
Biomedicine & Health· Notable
Mitochondrial proteome of Acanthamoeba delineates aerobic and anaerobic pathways dynamically regulated by oxygen
E 96I 51N 74
70
96
51
74
Early signalOct 1, 2026
31
Neuroscience· Notable
Transcriptomic convergence and the female protective effect in autism

Separately knocking down 18 autism genes in lab-grown neural cells lowered many of the same other autism genes

E 95I 59N 64
69
95
59
64
Early signalNov 4, 2026
32
Physics· Notable
Any-light-particle searches with ALPSII: First science results

A laser search for axions at DESY saw none, setting a limit more than 20 times tighter than similar experiments

E 88I 62N 64
69
88
62
64
Early signalNov 2, 2026
33
Neuroscience· Notable
Transcranial magnetic stimulation to the dorsolateral prefrontal cortex modulates single-neuron activity in humans

In four patients, single magnetic pulses to the prefrontal cortex changed firing in 46% of recorded neurons

E 91I 44N 72
69
91
44
72
Early signalNov 2, 2026
34
Neuroscience· Notable
Disruption of cell-type-specific molecular programs of striatal spiny projection neurons in autism
E 91I 63N 63
69
91
63
63
Early signalNov 1, 2026
35
Quantum· Notable
Simultaneous high-fidelity single-qubit gates in a spin qubit array
E 88I 71N 64
69
88
71
64
Early signalOct 15, 2026
36
Biomedicine & Health· Notable
Computational design of metalloproteases
E 93I 54N 71
69
93
54
71
Early signalOct 14, 2026
37
AI & Computing· Notable
Human–artificial intelligence collaboration for comanaging epilepsy in real time
E 93I 48N 73
69
93
48
73
Early signalOct 13, 2026
38
Biomedicine & Health· Notable
A DNA Typewriter records the cell lineage history of a mouse, from zygote to late organogenesis
E 96I 50N 72
69
96
50
72
Early signalOct 8, 2026
39
AI & Computing· Notable
Tangermeme: a toolkit for understanding cis-regulatory logic using deep learning models
E 91I 65N 68
69
91
65
68
Early signalOct 8, 2026
40
Physics· Notable
A nuclear clock synchronized to 229Th
E 94I 65N 65
69
94
65
65
Early signalOct 7, 2026
41
Biomedicine & Health· Notable
Comprehensive lineage tracing maps the landscape of cell fate decisions in mouse embryogenesis
E 96I 55N 69
69
96
55
69
Early signalOct 1, 2026
42
Neuroscience· Notable
A population code for semantics in human hippocampus
E 90I 58N 74
69
90
58
74
Early signalSep 30, 2026
43
Neuroscience· Notable
Lifespan single-cell transcriptomic atlas of the human prefrontal cortex
E 96I 56N 72
69
96
56
72
Early signalSep 23, 2026
44
Climate & Environment· Notable
The anthropogenic fingerprint on emerging infectious diseases
E 94I 62N 71
69
94
62
71
Early signalSep 23, 2026
45
Climate & Environment· Notable
Agricultural liming is a carbon sink in the Mississippi River Basin
E 94I 47N 76
69
94
47
76
Early signalSep 23, 2026
46
Biomedicine & Health· Notable
Cohesin prevents local mixing of condensed euchromatic domains in living human cells
E 91I 52N 79
69
91
52
79
Early signalSep 1, 2026
47
Neuroscience· Major
Sexual dimorphism in the complete Drosophila male central nervous system connectome

The first complete male fruit fly nervous system, brain and nerve cord, at synaptic resolution

E 97I 76N 67
69
97
76
67
Firming upSep 1, 2026
48
Biomedicine & Health· Notable
Predicting cellular responses to perturbation across diverse contexts with State

State predicts how cells' gene expression responds to perturbation, and flags strong perturbations in cellular contexts where it saw none in training.

E 94I 75N 67
69
94
75
67
Early signalAug 31, 2026
49
Materials & Energy· Notable
Scale-rich network-based metamaterials

Struts of many sizes let metamaterials combine direction-tunable stiffness with evenly spread deformation

E 94I 43N 68
68
94
43
68
Early signalNov 11, 2026
50
Neuroscience· Notable
Information formatting in neuronal populations predicts differential functional contributions to behavior

Two monkey brain areas format the same signals differently, and stimulating each changed choices differently

E 93I 45N 69
68
93
45
69
Early signalNov 10, 2026
Showing 50 of 390Show 50 moreShow all 390

Map of the current view

Novelty (x) by impact (y). Filter the index and the map follows.

Every score decomposes to its raw sources on the breakthrough page.last refreshed 2026-11-14How it is computed
AnalysisAll analysis

Deep dives from the Frontier desk

9 Nov 2026 · 33 min read

Science Breakthroughs This Week: 2-8 November 2026, Scored

The science of 2 to 8 November 2026, scored: 35 new results, led at 78 by a toxin tied to a deadly infant gut emergency and by ancient DNA on Germanic.

2 Nov 2026 · 26 min read

Science Breakthroughs This Week: 27 Oct-1 Nov 2026, Scored

The science breakthroughs of 27 October to 1 November 2026, scored: 30 new results, led at 72 by an explainable AI for attributing paintings, then a global map of threats to freshwater species and a single-cell atlas of immune genes at 70.

27 Oct 2026 · 23 min read

Science Breakthroughs This Week: 22-26 October 2026, Scored

The science breakthroughs of 22-26 October 2026, scored: 24 new results, led at 71 by a cold-induced metabolite in worms and an Angelman syndrome mechanism in mice.

21 Oct 2026 · 23 min read

Science Breakthroughs This Week: 15-21 October 2026, Scored

Frontier

The latest scientific discoveries, scored against their primary sources.

An open, evidence-graded index of recent breakthroughs in research and technology, with new work added daily. Every score decomposes to the records it came from, and is re-checked weekly.

The index

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The week's top new breakthroughs, scored, every Monday.
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The science breakthroughs of 15-21 October 2026, scored: 28 new results, led by a village-networks trial at 74 and two enzymes designed to cut proteins.

14 Oct 2026 · 22 min read

Science Breakthroughs This Week: 8-14 October 2026, Scored

The science breakthroughs of 8-14 October 2026, scored: 27 new results, led by biomedicine, with a genomics toolkit and a brain code for word meaning on top at 72.

7 Oct 2026 · 22 min read

Science Breakthroughs This Week: 1-7 October 2026, Scored

The science breakthroughs of 1-7 October 2026, scored: 29 new peer-reviewed results, led by biomedicine, with mitochondria across the tree of life on top at 74.

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  • © 2026 Frontier. Scores computed from open scholarly data, led by OpenAlex (CC0).

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    Dataset DOI 10.5281/zenodo.22750330