The latest scientific discoveries, scored.

Arc Institute's State transformer forecasts gene-expression responses in cell types it never trained on.

A multi-agent AI system on Gemini that generates and validates scientific hypotheses

The first complete male fruit fly nervous system, brain and nerve cord, at synaptic resolution

A telomere-to-telomere HG002 benchmark covering the diploid genome's hardest regions

In vivo editing of the PCSK9 gene produced durable cholesterol reductions in an early-stage trial.

First adult fruit fly connectome joining brain and ventral nerve cord

Only one deep-layer cortical output cell type gains categorical responses as mice learn to categorize sounds

Mass spec measures fluctuation energies for 5,778 protein domains in parallel

Ultrafast X-rays resolve the electron, proton, and solvent steps of proton-coupled electron transfer in water

Quantinuum reaches beyond-classical circuits without giving up the field's best gate fidelity.

Neuropixels probe fusing 960 recording sites with on-shank optogenetic light emitters

Ancient-DNA time series reveal hundreds of alleles under directional selection in humans

Magnetic quantum oscillations resolve the g-wave order parameter of the altermagnet CrSb in 3D

Nine trillion base pairs of training, a megabase of context, single-nucleotide resolution.

A precise single-letter edit reawakens protective fetal hemoglobin without cutting DNA.

Single-cell multiomic profiling maps hippocampal neurogenesis across ageing and Alzheimer's disease

After a personalized neoantigen mRNA vaccine, 11 of 14 TNBC patients stayed relapse-free for up to six years

A REG3A-to-KHSRP axonal loop brakes peripheral nerve regeneration through localized mRNA translation

One model predicts thousands of regulatory genomic tracks and tops specialist tools on variant effects.

A framework using Kolmogorov-Arnold networks to discover symbolic physical laws from data

A 4D-printed metamaterial absorber that reshapes on heating to retune its radar-band absorption

Bimagrumab plus semaglutide produced greater weight loss than either drug alone in a phase 2 trial

Pesticide residues rank as the second strongest driver of soil biodiversity across European soils

Five genomic factors explain most shared genetic risk across 14 psychiatric disorders

A generative model scaffolds enzyme active sites from functional-group positions alone, no residue order required.

Drug-loaded nanoparticles hijack skull immune cells to bypass the blood-brain barrier for stroke therapy

Electron-scattering line shapes cut estimated black-hole masses about a hundredfold.

Normal sleep raises plasma amyloid beta and tau versus sleep deprivation in a randomized crossover trial

A generative model builds active metallohydrolases straight from chemistry, no lab tinkering required.

An RL agent writes machine-checkable Lean proofs for competition mathematics.

A multimodal whole-slide foundation model for pathology that works without fine-tuning

An open model develops self-reflection and verification with no human reasoning examples.

A GPT-style model forecasts more than 1,000 diseases decades ahead and generates synthetic health records.

An open pipeline turns AlphaFold2 into nanomolar binders without high-throughput screening.

Adding two feedbacks that models usually ignore cuts the room left under 1.5 C by a quarter.

A single-cell map of bone-innervating sensory neurons identifies FGF9 as a driver of fracture repair

High-dimensional profiling reveals how a gene-edited pig organ is rejected, and how it holds.

An AI model generates spatial proteomics from H&E slides to improve lung cancer prognostic accuracy

Returned asteroid samples hold nucleobases, amino acids, and a first hint of tryptophan.

A subretinal photovoltaic implant plus infrared glasses gave most trial patients back central sight in a disease with no prior treatment.

A dedicated satellite resolves individual leaking sites across the planet's biggest fossil-fuel basins.

Gravitational-wave merger confirms horizon area grows and the remnant is Kerr

MoM-z14 at redshift 14.44 pushes the spectroscopic frontier of cosmic dawn.

A strongly binding phosphonic acid interlayer gives perovskite cells a T90 of nearly 3000 hours at 85°C

Homogenizing chlorine in perovskite films yields 27.2% certified solar-cell efficiency

Imagined sentences are decoded in real time, and a mental password stops the device from listening in.

A single AI beats operational forecasts for weather, air quality, ocean waves, and cyclones at a fraction of the compute.

An in vivo edit of the liver ANGPTL3 gene lowered triglycerides and LDL in a phase 1 trial.

Second-order out-of-time-order correlators stay sensitive where scrambling usually erases the dynamics.

A once-daily small-molecule drug cut body weight by double digits in a large phase 3 obesity trial.

A language model invented OpenCRISPR-1, a Cas9 hundreds of mutations from anything in nature.

A two-level, language-guided policy autonomously completes the clip-and-cut phase of gallbladder removal and corrects its own mistakes.

MICrONS fused live neural activity with a full wiring diagram of mouse visual cortex.

A Chinese fusion device holds plasma densities up to 65% above a barrier long thought to trigger disruption.

An intracranial biomarker forecasts response to BNST-NAc stimulation for treatment-refractory depression.

A computational method builds small proteins programmed to recognize chosen DNA targets and control nearby genes.

Haplotype-resolved assemblies close most remaining gaps and fully sequence 1,246 centromeres.

One fine-tuned model forecasts human choices across 160 psychology experiments.

A six-atom, all-nitrogen allotrope isolated and kept stable at cryogenic temperatures.

Fresh Gaia and Hubble data turn our Galaxy's long-assumed merger into a coin toss.

Three years of galaxy maps favor an evolving dark energy over Einstein's constant.

A cobalt-nickel core wrapped in doped ceria breaks the usual trade-off between how efficiently and how long a high-temperature CO2 catalyst runs.

The lightest planet ever seen in direct imaging, caught sculpting a gap in a young star's debris disc.

A targeted nanoparticle reprograms T cells into cancer fighters, skipping the factory.

Integrated photonics generates GKP states, a key ingredient for fault-tolerant light-based quantum computing.

The first personalized in vivo base-editing medicine, from diagnosis to dosing in about six months.

A blinded trial pits a medical language model against 20 primary care doctors on text consultations.

Long-term follow-up shows vaccine-induced T cells persist and track with delayed recurrence.

Generative AI builds serine hydrolases with efficiencies approaching natural proteins.

Satellites reveal a reversal of a decades-long freshening trend that tracks the loss of Antarctic sea ice.

A single infusion of stem-cell-derived islets restored insulin independence in most recipients.

Precision tritium spectroscopy pushes the electron-antineutrino mass below half an electronvolt.

One pretrained model predicts cortical responses to stimuli it never saw, and even reads out cell types and wiring.

In the MICrONS connectome, neurons that respond alike are preferentially wired together, and so are trained neural networks.

A generative model proposes crystals meeting target properties, and one was synthesized and measured.

A foundation model for spreadsheets outperforms tuned gradient-boosted trees on small data.

A mid-infrared spectrum points again at dimethyl sulfide, but still short of proof.

An interferometric parity measurement in InAs-Al nanowires, a building block a topological qubit would need.

A single carbon carrying four hydroxyl groups is synthesized in space-simulating ice for the first time.

Oxford teleports a logic gate between trapped-ion modules and runs Grover's search across the link.

Pristine asteroid material yields the most complete inventory of prebiotic molecules ever measured off Earth.

Linking tropical cloud change to ocean warming patterns halves the field's biggest uncertainty.

Mid-depth warming in the equatorial Atlantic points to a circulation slowdown that began decades ago.

Cat qubits suppress bit-flips in hardware so a small repetition code can handle the rest, below threshold.

Aurora entangles a cluster state across separate chips with 86.4 billion modes, over fiber, at room temperature.

The first complete wiring diagram of an adult fruit fly brain

A base-controlled reaction lets chemists insert either one or two nitrogen atoms into a five-membered carbon ring, choosing the product by swapping the base's cation.

An evolutionary coding agent finds new, provably correct algorithms and optimizes Google's own infrastructure.

Real-space maps confirm magnetism's newly recognized third class and show it can be controlled.

Quantinuum's 56-qubit processor produces over 70,000 bits of entropy verified by exascale classical computing.

Self-assembled iridium hydroxide keeps PEM electrolyzer performance high while slashing iridium loading.

A 105-qubit superconducting processor runs a sampling task no classical supercomputer could finish in the age of the universe.

An attribution study pins back-to-back record heat on El Nino stacked atop steady greenhouse warming.

Reversing warming later could take hundreds of gigatonnes of carbon removal, and may not be reversible at all.

A vision-language-action model drives real robots through dexterous, open-vocabulary tasks.

In-soil CO2 monitors directly measure carbon removal from basalt spread on a Virginia soybean field.

A panel-of-doctors language model reaches 85.5% accuracy on the toughest NEJM cases while cutting testing costs.

Two black holes inside the forbidden mass gap collide to make a 225-solar-mass remnant.

The definitive value of the muon's magnetic anomaly, pinned to 127 parts per billion.

A deep-learning model reconstructs typed sentences from brain scans, no surgery required.

A comet on a wildly hyperbolic orbit passes through the inner solar system.

The most distant galaxy yet confirmed deepens the puzzle of early bright galaxies.

The mission's debut data release maps 30 million objects across 63 square degrees of sky.