| 01 | Biomedicine & Health· Notable Tracing the spread of Germanic languages using ancient genomicsAncient DNA suggests Germanic may have reached Scandinavia some 800 years later than assumed E 93I 59N 82 | 78 | 93 | 59 | 82 | Early signal | Oct 28, 2026 |
| 02 | Physics· Notable Multimodal X-ray imaging reveals hierarchical fibre mechanicsA new X-ray method maps how collagen fibrils and fibres share load inside intact rat spinal discs E 91I 47N 85 | 77 | 91 | 47 | 85 | Early signal | Nov 4, 2026 |
| 03 | Biomedicine & Health· Notable Clostridium perfringens Delta toxin targets CD9 to drive NEC and brain injuryE 92I 37N 91 | 77 | 92 | 37 | 91 | Early signal | Oct 28, 2026 |
| 04 | Biomedicine & Health· Notable Population-scale single-nucleus multi-omic profiling of skeletal muscle reveals extensive context-specific genetic regulationSingle-nucleus maps of 287 muscle biopsies match almost 3,500 trait signals to regulatory variants E 93I 57N 77 | 75 | 93 | 57 | 77 | Early signal | Oct 28, 2026 |
| 05 | Biomedicine & Health· Notable Efficient and accurate mixed model association tool for single-cell eQTL analysisIn 1.2 million immune cells, a single-cell model found 48.8% more eGenes than a standard pooled pipeline E 90I 53N 78 | 74 | 90 | 53 | 78 | Early signal | Nov 6, 2026 |
| 06 | Biomedicine & Health· Notable Cross-species multiomic atlas of the primate basal gangliaE 91I 76N 67 | 74 | 91 | 76 | 67 | Early signal | Nov 1, 2026 |
| 07 | Biomedicine & Health· Notable Rare and common genetic variants shape single-cell immune gene expressionE 94I 63N 73 | 74 | 94 | 63 | 73 | Early signal | Oct 28, 2026 |
| 08 | AI & Computing· Notable An open vision-language model for diverse medical applicationsOpen medical AI models built on Gemma 3 beat their general-purpose base across medical images and text E 91I 96N 64 | 74 | 91 | 96 | 64 | Early signal | Oct 1, 2026 |
| 09 | Biomedicine & Health· Major MemBrain v2: an end-to-end tool for the analysis of membranes in cryo-electron tomographyE 88I 93N 71 | 74 | 88 | 93 | 71 | Firming up | Sep 8, 2026 |
| 10 | AI & Computing· Notable Generating interesting scientific ideas using knowledge graphs and LLMs: Evaluations with 100 research group leadersAsked to rate over 4,400 AI-generated ideas, 100-plus group leaders called a quarter interesting E 88I 63N 72 | 73 | 88 | 63 | 72 | Early signal | Nov 9, 2026 |
| 11 | Biomedicine & Health· Notable Eukaryotes’ closest relatives are internally simple syntrophic peptidotrophic archaeaE 92I 61N 74 | 73 | 92 | 61 | 74 | Early signal | Oct 28, 2026 |
| 12 | AI & Computing· Notable Reimagining research papers as interactive and reliable AI agentsE 94I 68N 76 | 73 | 94 | 68 | 76 | Early signal | Sep 16, 2026 |
| 13 | AI & Computing· Notable Intrinsically motivated humans and agents in open-world explorationChildren, adults and AI agents in a Minecraft-like game seem to seek novelty first, then control E 91I 57N 71 | 71 | 91 | 57 | 71 | Early signal | Nov 4, 2026 |
| 14 | Biomedicine & Health· Notable Tandem repeat variation shapes immune cell type-specific gene expressionRepeated stretches of DNA shape gene activity immune cell type by cell type, across 1,925 people E 94I 54N 72 | 71 | 94 | 54 | 72 | Early signal | Oct 28, 2026 |
| 15 | AI & Computing· Notable Sequential diagnosis with language modelsA language-model system simulating a panel of physicians correctly diagnosed 83.2% of NEJM case-conference cases in a benchmark, against 36.1% for generalist physicians. E 93I 81N 59 | 71 | 93 | 81 | 59 | Early signal | Oct 22, 2026 |
| 16 | Biomedicine & Health· Notable Comparative analysis of mitochondrial proteomes across the tree of lifeE 94I 57N 75 | 71 | 94 | 57 | 75 | Early signal | Oct 1, 2026 |
| 17 | Biomedicine & Health· Notable Robust fine-mapping in the presence of linkage disequilibrium mismatchA fine-mapping method holds up better than existing tools when the reference panel does not match the study E 91I 51N 70 | 70 | 91 | 51 | 70 | Early signal | Nov 6, 2026 |
| 18 | Biomedicine & Health· Notable A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneityA map of 12 glioblastomas finds their cells on one path, from development-like states to injury and low oxygen E 94I 48N 70 | 70 | 94 | 48 | 70 | Early signal | Nov 4, 2026 |
| 19 | Neuroscience· Notable Aggression experience and observation drive shared behavioural and neural changesMice that only watched fights later fought more like experienced fighters, with shared brain changes E 93I 45N 72 | 70 | 93 | 45 | 72 | Early signal | Nov 4, 2026 |
| 20 | Neuroscience· Notable An astrocyte-microglia MFG-E8 axis promotes synapse engulfment in early amyloid pathologyIn mice, astrocytes in an early bulbous state release a signal microglia need to eat the synapses beside them E 90I 48N 73 | 70 | 90 | 48 | 73 | Early signal | Nov 1, 2026 |
| 21 | Biomedicine & Health· Notable Pervasive patterns in bird songs resemble those in human speech and song and are independent of vocal learningE 94I 49N 70 | 70 | 94 | 49 | 70 | Early signal | Oct 29, 2026 |
| 22 | Biomedicine & Health· Notable MCT1-dependent mitochondrial lactate import sustains cardiac metabolismE 96I 49N 72 | 70 | 96 | 49 | 72 | Early signal | Oct 28, 2026 |
| 23 | Neuroscience· Notable Connectome simulations identify a central pattern generator for fly walkingE 96I 62N 65 | 70 | 96 | 62 | 65 | Early signal | Oct 28, 2026 |
| 24 | Biomedicine & Health· Notable Genetic variants shape single-cell chromatin accessibility and disease riskE 94I 50N 71 | 70 | 94 | 50 | 71 | Early signal | Oct 28, 2026 |
| 25 | Biomedicine & Health· Notable Steroid hormones produced by coral-associated Endozoicomonas influence coral immune response during thermal stressCoral bacteria make testosterone and progesterone, and giving corals either one shifts their immune genes E 91I 44N 77 | 70 | 91 | 44 | 77 | Early signal | Oct 22, 2026 |
| 26 | Neuroscience· Notable Functional architecture of the human insulaE 94I 50N 74 | 70 | 94 | 50 | 74 | Early signal | Oct 21, 2026 |
| 27 | Biomedicine & Health· Notable De novo design of cysteine proteasesE 91I 64N 70 | 70 | 91 | 64 | 70 | Early signal | Oct 14, 2026 |
| 28 | Other frontiers· Notable Educational intervention can rewire village social networksE 96I 39N 78 | 70 | 96 | 39 | 78 | Early signal | Oct 14, 2026 |
| 29 | Biomedicine & Health· Notable Prehistoric global migration of vanishing gut microbes with humansE 94I 50N 75 | 70 | 94 | 50 | 75 | Early signal | Oct 7, 2026 |
| 30 | Biomedicine & Health· Notable Mitochondrial proteome of Acanthamoeba delineates aerobic and anaerobic pathways dynamically regulated by oxygenE 96I 51N 74 | 70 | 96 | 51 | 74 | Early signal | Oct 1, 2026 |
| 31 | Neuroscience· Notable Transcriptomic convergence and the female protective effect in autismSeparately knocking down 18 autism genes in lab-grown neural cells lowered many of the same other autism genes E 95I 59N 64 | 69 | 95 | 59 | 64 | Early signal | Nov 4, 2026 |
| 32 | Physics· Notable Any-light-particle searches with ALPSII: First science resultsA laser search for axions at DESY saw none, setting a limit more than 20 times tighter than similar experiments E 88I 62N 64 | 69 | 88 | 62 | 64 | Early signal | Nov 2, 2026 |
| 33 | Neuroscience· Notable Transcranial magnetic stimulation to the dorsolateral prefrontal cortex modulates single-neuron activity in humansIn four patients, single magnetic pulses to the prefrontal cortex changed firing in 46% of recorded neurons E 91I 44N 72 | 69 | 91 | 44 | 72 | Early signal | Nov 2, 2026 |
| 34 | Neuroscience· Notable Disruption of cell-type-specific molecular programs of striatal spiny projection neurons in autismE 91I 63N 63 | 69 | 91 | 63 | 63 | Early signal | Nov 1, 2026 |
| 35 | Quantum· Notable Simultaneous high-fidelity single-qubit gates in a spin qubit arrayE 88I 71N 64 | 69 | 88 | 71 | 64 | Early signal | Oct 15, 2026 |
| 36 | Biomedicine & Health· Notable Computational design of metalloproteasesE 93I 54N 71 | 69 | 93 | 54 | 71 | Early signal | Oct 14, 2026 |
| 37 | AI & Computing· Notable Human–artificial intelligence collaboration for comanaging epilepsy in real timeE 93I 48N 73 | 69 | 93 | 48 | 73 | Early signal | Oct 13, 2026 |
| 38 | Biomedicine & Health· Notable A DNA Typewriter records the cell lineage history of a mouse, from zygote to late organogenesisE 96I 50N 72 | 69 | 96 | 50 | 72 | Early signal | Oct 8, 2026 |
| 39 | AI & Computing· Notable Tangermeme: a toolkit for understanding cis-regulatory logic using deep learning modelsE 91I 65N 68 | 69 | 91 | 65 | 68 | Early signal | Oct 8, 2026 |
| 40 | Physics· Notable A nuclear clock synchronized to 229ThE 94I 65N 65 | 69 | 94 | 65 | 65 | Early signal | Oct 7, 2026 |
| 41 | Biomedicine & Health· Notable Comprehensive lineage tracing maps the landscape of cell fate decisions in mouse embryogenesisE 96I 55N 69 | 69 | 96 | 55 | 69 | Early signal | Oct 1, 2026 |
| 42 | Neuroscience· Notable A population code for semantics in human hippocampusE 90I 58N 74 | 69 | 90 | 58 | 74 | Early signal | Sep 30, 2026 |
| 43 | Neuroscience· Notable Lifespan single-cell transcriptomic atlas of the human prefrontal cortexE 96I 56N 72 | 69 | 96 | 56 | 72 | Early signal | Sep 23, 2026 |
| 44 | Climate & Environment· Notable The anthropogenic fingerprint on emerging infectious diseasesE 94I 62N 71 | 69 | 94 | 62 | 71 | Early signal | Sep 23, 2026 |
| 45 | Climate & Environment· Notable Agricultural liming is a carbon sink in the Mississippi River BasinE 94I 47N 76 | 69 | 94 | 47 | 76 | Early signal | Sep 23, 2026 |
| 46 | Biomedicine & Health· Notable Cohesin prevents local mixing of condensed euchromatic domains in living human cellsE 91I 52N 79 | 69 | 91 | 52 | 79 | Early signal | Sep 1, 2026 |
| 47 | Neuroscience· Major Sexual dimorphism in the complete Drosophila male central nervous system connectomeThe first complete male fruit fly nervous system, brain and nerve cord, at synaptic resolution E 97I 76N 67 | 69 | 97 | 76 | 67 | Firming up | Sep 1, 2026 |
| 48 | Biomedicine & Health· Notable Predicting cellular responses to perturbation across diverse contexts with StateState predicts how cells' gene expression responds to perturbation, and flags strong perturbations in cellular contexts where it saw none in training. E 94I 75N 67 | 69 | 94 | 75 | 67 | Early signal | Aug 31, 2026 |
| 49 | Materials & Energy· Notable Scale-rich network-based metamaterialsStruts of many sizes let metamaterials combine direction-tunable stiffness with evenly spread deformation E 94I 43N 68 | 68 | 94 | 43 | 68 | Early signal | Nov 11, 2026 |
| 50 | Neuroscience· Notable Information formatting in neuronal populations predicts differential functional contributions to behaviorTwo monkey brain areas format the same signals differently, and stimulating each changed choices differently E 93I 45N 69 | 68 | 93 | 45 | 69 | Early signal | Nov 10, 2026 |