| 01 | Biomedicine & Health· Major MemBrain v2: an end-to-end tool for the analysis of membranes in cryo-electron tomographyE 88I 90N 72 | 76 | 88 | 90 | 72 | Firming up | Sep 8, 2026 |
| 02 | Biomedicine & Health· Notable Comparative analysis of mitochondrial proteomes across the tree of lifeE 92I 50N 76 | 73 | 92 | 50 | 76 | Early signal | Oct 1, 2026 |
| 03 | Biomedicine & Health· Notable Cohesin prevents local mixing of condensed euchromatic domains in living human cellsE 91I 55N 81 | 73 | 91 | 55 | 81 | Early signal | Sep 1, 2026 |
| 04 | AI & Computing· Notable Tangermeme: a toolkit for understanding cis-regulatory logic using deep learning modelsE 85I 67N 69 | 72 | 85 | 67 | 69 | Early signal | Oct 8, 2026 |
| 05 | Biomedicine & Health· Notable Mitochondrial proteome of Acanthamoeba delineates aerobic and anaerobic pathways dynamically regulated by oxygenE 94I 46N 75 | 72 | 94 | 46 | 75 | Early signal | Oct 1, 2026 |
| 06 | Neuroscience· Notable A population code for semantics in human hippocampusE 88I 56N 75 | 72 | 88 | 56 | 75 | Early signal | Sep 30, 2026 |
| 07 | AI & Computing· Notable Reimagining research papers as interactive and reliable AI agentsE 94I 54N 75 | 72 | 94 | 54 | 75 | Early signal | Sep 16, 2026 |
| 08 | Neuroscience· Notable What one sees depends on how far the eye has movedE 89I 41N 90 | 72 | 89 | 41 | 90 | Early signal | Aug 30, 2026 |
| 09 | Biomedicine & Health· Notable A DNA Typewriter records the cell lineage history of a mouse, from zygote to late organogenesisE 93I 44N 74 | 71 | 93 | 44 | 74 | Early signal | Oct 8, 2026 |
| 10 | AI & Computing· Notable Decoding systemic vascular health and hypertensive disorders in pregnancy through retinal imaging and Visionary AIE 86I 41N 80 | 71 | 86 | 41 | 80 | Early signal | Oct 6, 2026 |
| 11 | Climate & Environment· Notable Agricultural liming is a carbon sink in the Mississippi River BasinE 94I 44N 78 | 71 | 94 | 44 | 78 | Early signal | Sep 23, 2026 |
| 12 | Biomedicine & Health· Notable A Virtual Cell Model That Predicts How Cells React to Being PerturbedArc Institute's State transformer forecasts gene-expression responses in cell types it never trained on. E 94I 70N 69 | 71 | 94 | 70 | 69 | Early signal | Aug 31, 2026 |
| 13 | Biomedicine & Health· Notable Prehistoric global migration of vanishing gut microbes with humansE 89I 36N 77 | 70 | 89 | 36 | 77 | Early signal | Oct 7, 2026 |
| 14 | Materials & Energy· Notable X-ray liquidography decodes complex motions in azobenzene isomerizationE 94I 40N 77 | 70 | 94 | 40 | 77 | Early signal | Sep 30, 2026 |
| 15 | Neuroscience· Notable Lifespan single-cell transcriptomic atlas of the human prefrontal cortexE 96I 44N 75 | 70 | 96 | 44 | 75 | Early signal | Sep 23, 2026 |
| 16 | Biomedicine & Health· Notable In mice, a population of male germ cells show characteristics of nonapoptotic cell death during G0 arrestE 86I 40N 76 | 69 | 86 | 40 | 76 | Early signal | Oct 12, 2026 |
| 17 | Neuroscience· Notable Single-cell atlas of transcriptomic vulnerability across brain disordersE 96I 48N 70 | 69 | 96 | 48 | 70 | Early signal | Sep 23, 2026 |
| 18 | Physics· Notable Gravitational torque drives multidecadal variations in length of dayE 94I 44N 73 | 69 | 94 | 44 | 73 | Early signal | Sep 23, 2026 |
| 19 | Biomedicine & Health· Notable Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney InjuryE 76I 51N 73 | 68 | 76 | 51 | 73 | Early signal | Oct 14, 2026 |
| 20 | Neuroscience· Notable Shedding light on left hippocampal mGlu5 in Alzheimer’s diseaseE 88I 39N 73 | 68 | 88 | 39 | 73 | Early signal | Oct 12, 2026 |
| 21 | Physics· Notable A thorium-229 optical nuclear clock with feedback loopE 91I 49N 66 | 68 | 91 | 49 | 66 | Early signal | Oct 7, 2026 |
| 22 | Physics· Notable A nuclear clock synchronized to 229ThE 91I 50N 67 | 68 | 91 | 50 | 67 | Early signal | Oct 7, 2026 |
| 23 | Climate & Environment· Notable Deep learning of fossil pollen morphology reveals 25,000 y of ecological change in eastern African grasslandsE 89I 41N 74 | 68 | 89 | 41 | 74 | Early signal | Oct 2, 2026 |
| 24 | Biomedicine & Health· Notable Acanthamoeba ATP synthase structure reveals the TCA cycle is tethered to OXPHOSE 94I 44N 69 | 68 | 94 | 44 | 69 | Early signal | Oct 1, 2026 |
| 25 | Neuroscience· Notable Prion-like transmission of human tau strains in the mouse brainE 93I 55N 64 | 68 | 93 | 55 | 64 | Early signal | Sep 30, 2026 |
| 26 | Biomedicine & Health· Notable A transcription factor regulates development of a bacteria-housing eukaryotic cell through DNA damage mitigationE 91I 34N 77 | 68 | 91 | 34 | 77 | Early signal | Sep 24, 2026 |
| 27 | Neuroscience· Notable The lipidomic architecture of the mouse brainE 94I 51N 68 | 68 | 94 | 51 | 68 | Early signal | Sep 23, 2026 |
| 28 | Neuroscience· Notable Ultrafast venous and sagittal sinus constrictions in the brain driven by abdominal pressureE 93I 44N 73 | 68 | 93 | 44 | 73 | Early signal | Sep 23, 2026 |
| 29 | Biomedicine & Health· Notable Efficient differential expression analysis of large-scale single-cell transcriptomics data using DreamletE 89I 63N 64 | 68 | 89 | 63 | 64 | Early signal | Sep 23, 2026 |
| 30 | Biomedicine & Health· Notable Molecular-level observation of the self-assembly of a virus-like particleE 94I 46N 72 | 68 | 94 | 46 | 72 | Early signal | Sep 16, 2026 |
| 31 | Physics· Notable Discovery of an intrinsic non-Hermitian phase transition in a bulk condensed-matter systemE 94I 45N 73 | 68 | 94 | 45 | 73 | Early signal | Sep 10, 2026 |
| 32 | Space & Astronomy· Notable A spatial map of the atmospheric limb of a hot JupiterE 85I 49N 67 | 67 | 85 | 49 | 67 | Early signal | Oct 14, 2026 |
| 33 | Biomedicine & Health· Notable The genetic basis for the production of toxic quinolizidine alkaloids in lupinsE 78I 43N 74 | 67 | 78 | 43 | 74 | Early signal | Oct 8, 2026 |
| 34 | Space & Astronomy· Notable Incorporation of atmospheric components in planetary magma oceans through bubble–metal compoundsE 92I 38N 72 | 67 | 92 | 38 | 72 | Early signal | Oct 1, 2026 |
| 35 | Biomedicine & Health· Notable Comprehensive lineage tracing maps the landscape of cell fate decisions in mouse embryogenesisE 89I 41N 71 | 67 | 89 | 41 | 71 | Early signal | Oct 1, 2026 |
| 36 | Neuroscience· Notable Intrinsic rewards guide visual resource allocation via reinforcement learningE 86I 45N 70 | 67 | 86 | 45 | 70 | Early signal | Oct 1, 2026 |
| 37 | Biomedicine & Health· Notable A high-confidence plant mitochondrial proteome via protein correlation profilingE 92I 44N 69 | 67 | 92 | 44 | 69 | Early signal | Oct 1, 2026 |
| 38 | Biomedicine & Health· Notable Repeated marine-to-freshwater fish transitions reveal paleoenvironmental modulation of adaptive radiationE 88I 51N 67 | 67 | 88 | 51 | 67 | Early signal | Sep 30, 2026 |
| 39 | Biomedicine & Health· Notable Butterfly wing patterns in flight create powerful illusory motion cuesE 94I 37N 70 | 67 | 94 | 37 | 70 | Early signal | Sep 30, 2026 |
| 40 | Materials & Energy· Notable Phototropic and skototropic growth in inorganic filmsE 91I 33N 75 | 67 | 91 | 33 | 75 | Early signal | Sep 28, 2026 |
| 41 | Other frontiers· Notable Continuous UV irradiation played an inconclusive role in selecting the canonical genetic alphabetE 89I 37N 74 | 67 | 89 | 37 | 74 | Early signal | Sep 28, 2026 |
| 42 | Neuroscience· Notable Single-nucleus transcriptome-wide association study of human brain disordersE 96I 48N 67 | 67 | 96 | 48 | 67 | Early signal | Sep 23, 2026 |
| 43 | Biomedicine & Health· Notable Developmental xenocortication using human-derived organoids in miceE 94I 48N 69 | 67 | 94 | 48 | 69 | Early signal | Sep 16, 2026 |
| 44 | AI & Computing· Major Accelerating scientific discovery with Co-ScientistA multi-agent AI system on Gemini that generates and validates scientific hypotheses E 94I 88N 72 | 67 | 94 | 88 | 72 | Firming up | May 19, 2026 |
| 45 | Space & Astronomy· Notable Two families of multi-planet systems with distinct architectures and stellar hostsE 85I 48N 65 | 66 | 85 | 48 | 65 | Early signal | Oct 13, 2026 |
| 46 | Neuroscience· Notable Heterochronicity shapes brain network formationE 86I 39N 70 | 66 | 86 | 39 | 70 | Early signal | Oct 12, 2026 |
| 47 | AI & Computing· Notable Large language models unlock the ecology of species interactionsE 85I 56N 64 | 66 | 85 | 56 | 64 | Early signal | Oct 8, 2026 |
| 48 | Space & Astronomy· Notable Discovery of a second-generation planet candidate accreting onto a white dwarfE 90I 40N 68 | 66 | 90 | 40 | 68 | Early signal | Oct 5, 2026 |
| 49 | AI & Computing· Notable Scalable decision-making for games of imperfect informationE 94I 39N 68 | 66 | 94 | 39 | 68 | Early signal | Sep 30, 2026 |
| 50 | Biomedicine & Health· Notable Barrier immune memory is programmed by intestinal epithelial cell presentation of cytosol-delivered bacterial antigensE 91I 38N 70 | 66 | 91 | 38 | 70 | Early signal | Sep 30, 2026 |
| 51 | Biomedicine & Health· Notable Host cell traversal by Plasmodium parasites drives sterilizing T cell-mediated immunity following immunizationE 91I 42N 67 | 66 | 91 | 42 | 67 | Early signal | Sep 30, 2026 |
| 52 | Neuroscience· Notable Comprehensive profiling of brain dynamics during anesthesia across phylogenyE 91I 41N 70 | 66 | 91 | 41 | 70 | Early signal | Sep 29, 2026 |
| 53 | Neuroscience· Notable Single-nucleus atlas of cell-type specific genetic regulation in the human brainE 93I 44N 67 | 66 | 93 | 44 | 67 | Early signal | Sep 23, 2026 |
| 54 | Climate & Environment· Notable The anthropogenic fingerprint on emerging infectious diseasesE 91I 44N 68 | 66 | 91 | 44 | 68 | Early signal | Sep 23, 2026 |
| 55 | Biomedicine & Health· Notable Lsp2 links early-life diet to adult translation and lifespan in DrosophilaE 94I 40N 68 | 66 | 94 | 40 | 68 | Early signal | Sep 23, 2026 |
| 56 | Neuroscience· Notable System-level synchronization and subtype-specific modules govern brain-wide serotonin axon innervationE 91I 31N 75 | 66 | 91 | 31 | 75 | Early signal | Sep 22, 2026 |
| 57 | Physics· Notable Disorder-promoted stabilityE 91I 41N 71 | 66 | 91 | 41 | 71 | Early signal | Sep 17, 2026 |
| 58 | Neuroscience· Notable Sexual dimorphism in the complete Drosophila male central nervous system connectomeThe first complete male fruit fly nervous system, brain and nerve cord, at synaptic resolution E 94I 55N 66 | 66 | 94 | 55 | 66 | Early signal | Sep 1, 2026 |
| 59 | Biomedicine & Health· Notable Effect of Vasopressin Initiation Threshold on Septic Shock MortalityE 84I 49N 65 | 65 | 84 | 49 | 65 | Early signal | Oct 14, 2026 |
| 60 | AI & Computing· Notable Advancing mathematics research with AI-driven formal proof searchE 88I 57N 58 | 65 | 88 | 57 | 58 | Early signal | Oct 8, 2026 |
| 61 | Neuroscience· Notable Human claustrum neurons encode uncertainty and prediction errors during aversive learningE 86I 39N 68 | 65 | 86 | 39 | 68 | Early signal | Oct 6, 2026 |
| 62 | Neuroscience· Notable An amygdala to anterior hypothalamic circuit gates stress sensitivityE 92I 37N 67 | 65 | 92 | 37 | 67 | Early signal | Sep 30, 2026 |
| 63 | Biomedicine & Health· Notable The Mader model of muscle energy metabolism simulates key metabolic exercise phenomenaE 91I 44N 66 | 65 | 91 | 44 | 66 | Early signal | Sep 28, 2026 |
| 64 | Biomedicine & Health· Notable Systematic mapping of bacteriophage gene essentiality with HIDEN-SEQE 89I 40N 69 | 65 | 89 | 40 | 69 | Early signal | Sep 25, 2026 |
| 65 | Biomedicine & Health· Notable Rapid genome-wide purging following tsunami-induced hybridization in a stickleback populationE 89I 41N 68 | 65 | 89 | 41 | 68 | Early signal | Sep 25, 2026 |
| 66 | Neuroscience· Notable Dynamic attribute activation explains gaze biases in choiceE 91I 39N 68 | 65 | 91 | 39 | 68 | Early signal | Sep 25, 2026 |
| 67 | Climate & Environment· Notable Rewriting the history of the invasive spiny water flea in North AmericaE 91I 39N 68 | 65 | 91 | 39 | 68 | Early signal | Sep 24, 2026 |
| 68 | Biomedicine & Health· Notable Reference genomes and fossils revise bat family phylogeny and biogeographyE 96I 43N 65 | 65 | 96 | 43 | 65 | Early signal | Sep 23, 2026 |
| 69 | Biomedicine & Health· Notable Structural diversification of phage tail fibers enables recognition of diverse type IV piliE 88I 42N 69 | 65 | 88 | 42 | 69 | Early signal | Sep 22, 2026 |
| 70 | Space & Astronomy· Notable Meteoritic organic matter records primitive oxygen reservoirs of the solar systemE 91I 35N 72 | 65 | 91 | 35 | 72 | Early signal | Sep 21, 2026 |
| 71 | Biomedicine & Health· Notable TM184C is a GPCR-like regulator of intercellular exchange and autophagyE 96I 37N 70 | 65 | 96 | 37 | 70 | Early signal | Sep 9, 2026 |
| 72 | Other frontiers· Notable Heel-strike mechanics reveal evolutionary trade-offs in hominin bipedalismE 91I 34N 74 | 65 | 91 | 34 | 74 | Early signal | Sep 8, 2026 |
| 73 | Climate & Environment· Notable Field experiments predict ecological response to a large-scale epidemic of an anti-keystone pathogenE 86I 37N 68 | 64 | 86 | 37 | 68 | Early signal | Oct 12, 2026 |
| 74 | AI & Computing· Notable Retrofitting language models to operate over bytesE 89I 40N 64 | 64 | 89 | 40 | 64 | Early signal | Oct 7, 2026 |
| 75 | Biomedicine & Health· Notable Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cyclingE 81I 41N 70 | 64 | 81 | 41 | 70 | Early signal | Oct 1, 2026 |
| 76 | Neuroscience· Notable Selfish and prosocial individuals both distort their actions’ impact, but selfish distortions can be more contagiousE 91I 37N 66 | 64 | 91 | 37 | 66 | Early signal | Oct 1, 2026 |
| 77 | Other frontiers· Notable Defensive networks provide basis for late pre-Hispanic Andean politiesE 91I 36N 67 | 64 | 91 | 36 | 67 | Early signal | Oct 1, 2026 |
| 78 | Biomedicine & Health· Notable Loss of the tumor suppressor p53 generates a signaling gradient that drives epithelial clonal expansionE 81I 39N 71 | 64 | 81 | 39 | 71 | Early signal | Oct 1, 2026 |
| 79 | AI & Computing· Notable Function-preserving watermarking of AI-generated proteinsE 92I 40N 64 | 64 | 92 | 40 | 64 | Early signal | Sep 30, 2026 |
| 80 | Biomedicine & Health· Notable Sugar-rich foods exacerbate antibiotic-induced microbiome disruptionE 94I 36N 65 | 64 | 94 | 36 | 65 | Early signal | Sep 30, 2026 |
| 81 | Neuroscience· Notable Loss of cerebral autoregulation drives abnormal perfusion patterns after strokeE 91I 36N 68 | 64 | 91 | 36 | 68 | Early signal | Sep 29, 2026 |
| 82 | Biomedicine & Health· Notable Phosphoproteomic dysregulation promotes tumor proliferation in Cushing’s diseaseE 93I 35N 67 | 64 | 93 | 35 | 67 | Early signal | Sep 29, 2026 |
| 83 | Climate & Environment· Notable Uneven attention to climate tipping pointsE 89I 35N 68 | 64 | 89 | 35 | 68 | Early signal | Sep 28, 2026 |
| 84 | Physics· Notable Transient chaos in the self-organization of dissipative optical solitonsE 91I 33N 70 | 64 | 91 | 33 | 70 | Early signal | Sep 25, 2026 |
| 85 | Neuroscience· Notable Intracranial recordings in humans reveal differential contributions of medial and lateral orbitofrontal cortex to approach–avoidance decision-makingE 91I 45N 65 | 64 | 91 | 45 | 65 | Early signal | Sep 15, 2026 |
| 86 | Biomedicine & Health· Notable Phenomic profiles and disease patterns of 1.9 million participants from Our Future HealthE 91I 39N 68 | 64 | 91 | 39 | 68 | Early signal | Sep 10, 2026 |
| 87 | Other frontiers· Notable Ancient proteins identify various Denisovan remains from Southwest ChinaE 94I 48N 63 | 64 | 94 | 48 | 63 | Early signal | Sep 9, 2026 |
| 88 | Biomedicine & Health· Major A complete diploid human genome benchmark for personalized genomicsA telomere-to-telomere HG002 benchmark covering the diploid genome's hardest regions E 96I 66N 61 | 64 | 96 | 66 | 61 | Firming up | Aug 1, 2026 |
| 89 | Biomedicine & Health· Major A Single Base-Editing Infusion Cuts LDL Cholesterol Up to 62%In vivo editing of the PCSK9 gene produced durable cholesterol reductions in an early-stage trial. E 97I 65N 73 | 64 | 97 | 65 | 73 | Firming up | May 25, 2026 |
| 90 | Biomedicine & Health· Notable Interventions to mitigate post-infection morbidity: Management insights from simple modelsE 86I 40N 63 | 63 | 86 | 40 | 63 | Early signal | Oct 9, 2026 |
| 91 | Space & Astronomy· Notable A fast radio burst at redshift 2, three billion years after the Big BangE 89I 40N 62 | 63 | 89 | 40 | 62 | Early signal | Oct 8, 2026 |
| 92 | Biomedicine & Health· Notable Disruption of the Nav1.8/Ankyrin-3 interaction in nociceptors reduces pathological pain-like behaviors in miceE 86I 41N 65 | 63 | 86 | 41 | 65 | Early signal | Oct 1, 2026 |
| 93 | Biomedicine & Health· Notable Osteoclasts intercept meningeal lymphatic paths for dural metastasisE 81I 39N 70 | 63 | 81 | 39 | 70 | Early signal | Sep 30, 2026 |
| 94 | Quantum· Notable Twisted Rényi negativity as a reliable proxy for mixed-state entanglement in fermionic systemsE 89I 35N 66 | 63 | 89 | 35 | 66 | Early signal | Sep 29, 2026 |
| 95 | Neuroscience· Notable Functional brain networks underlying approach–avoidance conflict processing in humans and ratsE 89I 37N 66 | 63 | 89 | 37 | 66 | Early signal | Sep 29, 2026 |
| 96 | AI & Computing· Notable Large-scale semidefinite programming with graphics processing unitsE 89I 37N 65 | 63 | 89 | 37 | 65 | Early signal | Sep 28, 2026 |
| 97 | Biomedicine & Health· Notable Mechanical stress remodelling drives epithelial–mesenchymal transition in the tumour microenvironmentE 80I 39N 70 | 63 | 80 | 39 | 70 | Early signal | Sep 28, 2026 |
| 98 | Quantum· Notable Aharonov–Bohm interference in a Z2 lattice gauge theory on a hybrid qubit–oscillator quantum computerE 88I 42N 65 | 63 | 88 | 42 | 65 | Early signal | Sep 25, 2026 |
| 99 | Physics· Notable Lu+ optical frequency references with accuracy verified at the 19th digitE 96I 39N 63 | 63 | 96 | 39 | 63 | Early signal | Sep 23, 2026 |
| 100 | Biomedicine & Health· Notable Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer DiagnosisE 85I 47N 63 | 63 | 85 | 47 | 63 | Early signal | Sep 22, 2026 |
