| 01 | Climate & Environment· Notable Increased demographic turnover and isolation precede social fragmentation in Asian elephantsE 91I 44N 67 | 67 | 91 | 44 | 67 | Early signal | Nov 12, 2026 |
| 02 | Biomedicine & Health· Notable Early epidemiological and spatial assessment of the Bundibugyo virus outbreak 2026E 78I 48N 57 | 60 | 78 | 48 | 57 | Early signal | Nov 12, 2026 |
| 03 | Materials & Energy· Notable Scale-rich network-based metamaterialsStruts of many sizes let metamaterials combine direction-tunable stiffness with evenly spread deformation E 94I 43N 68 | 68 | 94 | 43 | 68 | Early signal | Nov 11, 2026 |
| 04 | Biomedicine & Health· Notable Validation of clinical and preclinical obesity across global cohortsE 89I 49N 66 | 67 | 89 | 49 | 66 | Early signal | Nov 11, 2026 |
| 05 | Biomedicine & Health· Notable Prevention of Venous Thromboembolism after Total Hip or Knee ReplacementAfter hip or knee replacement, aspirin could not be shown as effective as anticoagulants, nor they as safe as aspirin E 83I 39N 73 | 66 | 83 | 39 | 73 | Early signal | Nov 11, 2026 |
| 06 | Space & Astronomy· Notable Independent interferometric observable confirms black hole shadow in M87*E 89I 43N 63 | 64 | 89 | 43 | 63 | Early signal | Nov 11, 2026 |
| 07 | Climate & Environment· Notable Human land use drives microplastic abundance in terrestrial wildlifeTapirs and anteaters ranging closer to development and waste sites carried more microplastics in their blood E 92I 31N 64 | 62 | 92 | 31 | 64 | Early signal | Nov 11, 2026 |
| 08 | Biomedicine & Health· Notable Intismeran Autogene plus Pembrolizumab for Resected Stage IIB to IV MelanomaA personalized neoantigen therapy plus pembrolizumab prolonged recurrence-free survival in a phase 3 melanoma trial E 83I 36N 59 | 59 | 83 | 36 | 59 | Early signal | Nov 11, 2026 |
| 09 | Neuroscience· Notable Information formatting in neuronal populations predicts differential functional contributions to behaviorTwo monkey brain areas format the same signals differently, and stimulating each changed choices differently E 93I 45N 69 | 68 | 93 | 45 | 69 | Early signal | Nov 10, 2026 |
| 10 | Physics· Notable Atomically resolved superconducting gap in (La,Pr)3Ni2O7 filmsAtomic-scale spectra point to a fully opened superconducting gap in oxygen-sufficient bilayer nickelate films E 88I 51N 53 | 61 | 88 | 51 | 53 | Early signal | Nov 10, 2026 |
| 11 | AI & Computing· Notable Generating interesting scientific ideas using knowledge graphs and LLMs: Evaluations with 100 research group leadersAsked to rate over 4,400 AI-generated ideas, 100-plus group leaders called a quarter interesting E 88I 63N 72 | 73 | 88 | 63 | 72 | Early signal | Nov 9, 2026 |
| 12 | Quantum· Notable Extensive mixed-state entanglement in kinetically constrained superradianceTheory predicts that a local constraint lets a burst of superradiance entangle the emitting atoms E 88I 44N 53 | 59 | 88 | 44 | 53 | Early signal | Nov 9, 2026 |
| 13 | Quantum· Notable Controlling Rydberg atom-polariton interactions: from exceptional points to fast readoutA single atom read out by the cloud next door, after three regimes of light-matter interaction are mapped E 88I 50N 49 | 58 | 88 | 50 | 49 | Early signal | Nov 9, 2026 |
| 14 | Biomedicine & Health· Notable Efficient and accurate mixed model association tool for single-cell eQTL analysisIn 1.2 million immune cells, a single-cell model found 48.8% more eGenes than a standard pooled pipeline E 90I 53N 78 | 74 | 90 | 53 | 78 | Early signal | Nov 6, 2026 |
| 15 | Biomedicine & Health· Notable Robust fine-mapping in the presence of linkage disequilibrium mismatchA fine-mapping method holds up better than existing tools when the reference panel does not match the study E 91I 51N 70 | 70 | 91 | 51 | 70 | Early signal | Nov 6, 2026 |
| 16 | Quantum· Notable Conserved quantities enable the quantum Mpemba effect in weakly open systemsWeakly open quantum systems started in thermal states need extra conserved quantities to show the Mpemba effect E 86I 53N 52 | 60 | 86 | 53 | 52 | Early signal | Nov 6, 2026 |
| 17 | Materials & Energy· Notable Atomically resolved exciton emission from single defects in MoS2Atom-scale light maps trace a common defect glow in the semiconductor MoS2 to carbon-hydrogen complexes E 88I 44N 70 | 67 | 88 | 44 | 70 | Early signal | Nov 5, 2026 |
| 18 | AI & Computing· Notable Denoising the US Census: Succinct block hierarchical regressionA new algorithm could make 2020 Census tables more accurate without weakening their privacy protection E 89I 49N 62 | 64 | 89 | 49 | 62 | Early signal | Nov 5, 2026 |
| 19 | Physics· Notable Seafloor geodesy delineates fast megathrust relocking after the giant 2011 Tohoku earthquakeMeasurements and models indicate the fault behind the 2011 Tohoku quake is locked again, as before it struck E 78I 38N 66 | 62 | 78 | 38 | 66 | Early signal | Nov 5, 2026 |
| 20 | Physics· Notable Equivalence of pseudogap and pairing energy in a cuprate high-temperature superconductorElectron pairing sets in at the pseudogap energy in a cuprate superconductor, noise measurements show E 91I 50N 49 | 59 | 91 | 50 | 49 | Early signal | Nov 5, 2026 |
| 21 | Physics· Notable Multimodal X-ray imaging reveals hierarchical fibre mechanicsA new X-ray method maps how collagen fibrils and fibres share load inside intact rat spinal discs E 91I 47N 85 | 77 | 91 | 47 | 85 | Early signal | Nov 4, 2026 |
| 22 | AI & Computing· Notable Intrinsically motivated humans and agents in open-world explorationChildren, adults and AI agents in a Minecraft-like game seem to seek novelty first, then control E 91I 57N 71 | 71 | 91 | 57 | 71 | Early signal | Nov 4, 2026 |
| 23 | Biomedicine & Health· Notable A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneityA map of 12 glioblastomas finds their cells on one path, from development-like states to injury and low oxygen E 94I 48N 70 | 70 | 94 | 48 | 70 | Early signal | Nov 4, 2026 |
| 24 | Neuroscience· Notable Aggression experience and observation drive shared behavioural and neural changesMice that only watched fights later fought more like experienced fighters, with shared brain changes E 93I 45N 72 | 70 | 93 | 45 | 72 | Early signal | Nov 4, 2026 |
| 25 | Neuroscience· Notable Transcriptomic convergence and the female protective effect in autismSeparately knocking down 18 autism genes in lab-grown neural cells lowered many of the same other autism genes E 95I 59N 64 | 69 | 95 | 59 | 64 | Early signal | Nov 4, 2026 |
| 26 | Quantum· Notable Observation of prethermal dynamical phase transitions and resonant meltingAn atom simulator running up to 180 qubits finds quantum states that hold off thermalization E 91I 50N 64 | 67 | 91 | 50 | 64 | Early signal | Nov 4, 2026 |
| 27 | Space & Astronomy· Notable Exorcising ghosts with gravitational wavesPulsars and a neutron-star merger set a lower mass limit on the extra modes of 'ghostful' quadratic gravity E 86I 45N 68 | 66 | 86 | 45 | 68 | Early signal | Nov 4, 2026 |
| 28 | Biomedicine & Health· Notable Cancer-selective gene circuits via intrinsic ribosomal frameshiftingA gene circuit keyed to a slip in the ribosome's reading frame makes cancer cells kill themselves in mice E 81I 30N 77 | 66 | 81 | 30 | 77 | Early signal | Nov 4, 2026 |
| 29 | Materials & Energy· Notable Twist-angle-dependent quantum phase diagrams in moiré bilayer MoTe2Across fifteen devices, 3.79° to 5.76° of twist takes two atom-thin sheets to superconductivity E 91I 56N 54 | 63 | 91 | 56 | 54 | Early signal | Nov 4, 2026 |
| 30 | Space & Astronomy· Notable Modified Newtonian Dynamics and galaxy clustersAcross 106 galaxy clusters, MOND needs 4 to 10 times less mass than Newton but still some unseen matter E 86I 30N 66 | 62 | 86 | 30 | 66 | Early signal | Nov 4, 2026 |
| 31 | Physics· Notable Any-light-particle searches with ALPSII: First science resultsA laser search for axions at DESY saw none, setting a limit more than 20 times tighter than similar experiments E 88I 62N 64 | 69 | 88 | 62 | 64 | Early signal | Nov 2, 2026 |
| 32 | Neuroscience· Notable Transcranial magnetic stimulation to the dorsolateral prefrontal cortex modulates single-neuron activity in humansIn four patients, single magnetic pulses to the prefrontal cortex changed firing in 46% of recorded neurons E 91I 44N 72 | 69 | 91 | 44 | 72 | Early signal | Nov 2, 2026 |
| 33 | Biomedicine & Health· Notable TAVR in Patients with Moderate Aortic Stenosis with At-Risk FeaturesValve replacement cut combined 2-year death or heart-failure events to 16.7% from 23.9% in at-risk moderate stenosis E 83I 44N 60 | 61 | 83 | 44 | 60 | Early signal | Nov 2, 2026 |
| 34 | Biomedicine & Health· Notable Global, regional and national burden of cervical cancer in 1990–2023 with forecasts to 2050: a Global Burden of Disease studyCervical cancer killed an estimated 369,000 women in 2023, and deaths are forecast to rise by 2050 E 88I 55N 50 | 60 | 88 | 55 | 50 | Early signal | Nov 2, 2026 |
| 35 | Climate & Environment· Notable Thermal ecology drives alternate responses to rising temperatures in Caribbean anolesAnole lizards of closed Caribbean forests raised their heat tolerance by 2 °C on average in a decade E 89I 0N 69 | 56 | 89 | 0 | 69 | Early signal | Nov 2, 2026 |
| 36 | Biomedicine & Health· Notable Cross-species multiomic atlas of the primate basal gangliaE 91I 76N 67 | 74 | 91 | 76 | 67 | Early signal | Nov 1, 2026 |
| 37 | Neuroscience· Notable An astrocyte-microglia MFG-E8 axis promotes synapse engulfment in early amyloid pathologyIn mice, astrocytes in an early bulbous state release a signal microglia need to eat the synapses beside them E 90I 48N 73 | 70 | 90 | 48 | 73 | Early signal | Nov 1, 2026 |
| 38 | Neuroscience· Notable Disruption of cell-type-specific molecular programs of striatal spiny projection neurons in autismE 91I 63N 63 | 69 | 91 | 63 | 63 | Early signal | Nov 1, 2026 |
| 39 | Biomedicine & Health· Notable Efficacy and safety of efinopegdutide in adults with metabolic dysfunction-associated steatohepatitis and stage 2–3 fibrosis: a phase 2b, randomised, placebo-controlled studySteatohepatitis resolved in over half of patients analysed on each dose of a GLP-1-glucagon drug, vs 13% on placebo E 80I 36N 67 | 61 | 80 | 36 | 67 | Early signal | Nov 1, 2026 |
| 40 | Biomedicine & Health· Notable Long-term outcomes after percutaneous coronary intervention with drug-eluting stents versus coronary artery bypass grafting for left main coronary artery disease: a prospective analysis of the multicentre IRIS-MAIN registryAt 10 years, a registry found no detectable survival difference between stents and bypass surgery E 80I 38N 64 | 61 | 80 | 38 | 64 | Early signal | Nov 1, 2026 |
| 41 | Biomedicine & Health· Notable Risovalisib for PIK3CA-mutated recurrent or persistent ovarian clear cell carcinoma: a single-arm, multicentre, phase 2 trialA targeted pill shrank PIK3CA-mutated ovarian clear cell tumours in 35% of evaluable trial patients E 77I 36N 66 | 60 | 77 | 36 | 66 | Early signal | Nov 1, 2026 |
| 42 | Biomedicine & Health· Notable Activity and safety of first-line pumitamig plus nab-paclitaxel in triple-negative breast cancer: a single-arm, phase 1b/2 trialA two-target antibody with chemotherapy shrank tumours in 31 of 42 triple-negative breast cancers E 77I 34N 65 | 59 | 77 | 34 | 65 | Early signal | Nov 1, 2026 |
| 43 | Biomedicine & Health· Notable Nuclear NAD + promotes innate immune memory by inhibiting KDM5A-dependent histone demethylationE 78I 37N 79 | 67 | 78 | 37 | 79 | Early signal | Oct 30, 2026 |
| 44 | Materials & Energy· Notable One-minute frequency disturbances from unintended synchronization in cyber–physical power systemsE 88I 40N 65 | 63 | 88 | 40 | 65 | Early signal | Oct 30, 2026 |
| 45 | Biomedicine & Health· Notable Pervasive patterns in bird songs resemble those in human speech and song and are independent of vocal learningE 94I 49N 70 | 70 | 94 | 49 | 70 | Early signal | Oct 29, 2026 |
| 46 | Physics· Notable Altermagnetism revealed by polarized neutrons in MnF2E 91I 64N 60 | 68 | 91 | 64 | 60 | Early signal | Oct 29, 2026 |
| 47 | Physics· Notable Chiral altermagnon in MnTeX-rays catch a one-handed spin wave in manganese telluride, just as a candidate new kind of magnet predicts E 91I 56N 66 | 68 | 91 | 56 | 66 | Early signal | Oct 29, 2026 |
| 48 | Neuroscience· Notable Intrinsic gestational timing governs human cerebellar development after preterm birthE 91I 45N 70 | 68 | 91 | 45 | 70 | Early signal | Oct 29, 2026 |
| 49 | Materials & Energy· Notable Free-standing two-dimensional metal oxides at the single-atomic-layer limitE 91I 44N 69 | 67 | 91 | 44 | 69 | Early signal | Oct 29, 2026 |
| 50 | Climate & Environment· Notable The global geography of threats to freshwater biodiversityE 92I 27N 74 | 66 | 92 | 27 | 74 | Early signal | Oct 29, 2026 |
| 51 | Space & Astronomy· Notable A Martian meteorite that formed ≳4.1 billion years ago samples Mars’ early crust and mantleE 96I 36N 68 | 66 | 96 | 36 | 68 | Early signal | Oct 29, 2026 |
| 52 | Biomedicine & Health· Notable Planetary-scale metagenomic analysis reveals CRISPR targeting dynamics across ecosystemsE 91I 54N 62 | 66 | 91 | 54 | 62 | Early signal | Oct 29, 2026 |
| 53 | AI & Computing· Notable Foundation model for particle collision data analysisPretrained on 500 million simulated collisions, one model handles new searches and rediscovers a known particle E 88I 52N 60 | 64 | 88 | 52 | 60 | Early signal | Oct 29, 2026 |
| 54 | Biomedicine & Health· Notable Genomic analysis of early case samples from the 2025 Marburg virus outbreak in EthiopiaSeven genomes from Ethiopia's first Marburg outbreak point to one spillover, then human-to-human spread E 89I 38N 64 | 62 | 89 | 38 | 64 | Early signal | Oct 29, 2026 |
| 55 | Biomedicine & Health· Notable Rapid longitudinal flights cause time shifts and Sun compass errorE 94I 0N 76 | 60 | 94 | 0 | 76 | Early signal | Oct 29, 2026 |
| 56 | Mathematics· Notable The ABCD hypothesisE 91I 0N 68 | 56 | 91 | 0 | 68 | Early signal | Oct 29, 2026 |
| 57 | Physics· Notable Hydration at the base of the mantle transition zone by ancient subductions in AsiaE 91I 0N 67 | 55 | 91 | 0 | 67 | Early signal | Oct 29, 2026 |
| 58 | Climate & Environment· Notable Global bee bioregions mirror those of other taxa despite a uniquely bimodal latitudinal diversity gradientE 91I 0N 64 | 54 | 91 | 0 | 64 | Early signal | Oct 29, 2026 |
| 59 | Biomedicine & Health· Notable Tracing the spread of Germanic languages using ancient genomicsAncient DNA suggests Germanic may have reached Scandinavia some 800 years later than assumed E 93I 59N 82 | 78 | 93 | 59 | 82 | Early signal | Oct 28, 2026 |
| 60 | Biomedicine & Health· Notable Clostridium perfringens Delta toxin targets CD9 to drive NEC and brain injuryE 92I 37N 91 | 77 | 92 | 37 | 91 | Early signal | Oct 28, 2026 |
| 61 | Biomedicine & Health· Notable Population-scale single-nucleus multi-omic profiling of skeletal muscle reveals extensive context-specific genetic regulationSingle-nucleus maps of 287 muscle biopsies match almost 3,500 trait signals to regulatory variants E 93I 57N 77 | 75 | 93 | 57 | 77 | Early signal | Oct 28, 2026 |
| 62 | Biomedicine & Health· Notable Rare and common genetic variants shape single-cell immune gene expressionE 94I 63N 73 | 74 | 94 | 63 | 73 | Early signal | Oct 28, 2026 |
| 63 | Biomedicine & Health· Notable Eukaryotes’ closest relatives are internally simple syntrophic peptidotrophic archaeaE 92I 61N 74 | 73 | 92 | 61 | 74 | Early signal | Oct 28, 2026 |
| 64 | Biomedicine & Health· Notable Tandem repeat variation shapes immune cell type-specific gene expressionRepeated stretches of DNA shape gene activity immune cell type by cell type, across 1,925 people E 94I 54N 72 | 71 | 94 | 54 | 72 | Early signal | Oct 28, 2026 |
| 65 | Biomedicine & Health· Notable MCT1-dependent mitochondrial lactate import sustains cardiac metabolismE 96I 49N 72 | 70 | 96 | 49 | 72 | Early signal | Oct 28, 2026 |
| 66 | Neuroscience· Notable Connectome simulations identify a central pattern generator for fly walkingE 96I 62N 65 | 70 | 96 | 62 | 65 | Early signal | Oct 28, 2026 |
| 67 | Biomedicine & Health· Notable Genetic variants shape single-cell chromatin accessibility and disease riskE 94I 50N 71 | 70 | 94 | 50 | 71 | Early signal | Oct 28, 2026 |
| 68 | Physics· Notable Defining and measuring proximity to criticality based on univariate time seriesE 91I 57N 65 | 68 | 91 | 57 | 65 | Early signal | Oct 28, 2026 |
| 69 | Neuroscience· Notable Emotion regulation capacity lacks a shared neural signatureE 94I 48N 68 | 68 | 94 | 48 | 68 | Early signal | Oct 28, 2026 |
| 70 | Physics· Notable Time-reversal-symmetry-breaking spin injection from a compensated magnetA magnet with no net magnetization still injects a spin current, and reversing its state flips the signal E 91I 52N 64 | 67 | 91 | 52 | 64 | Early signal | Oct 28, 2026 |
| 71 | Biomedicine & Health· Notable Dengue virus controlled human challenge reveals that preexisting immunity shapes viral replication and broadly protective responsesE 88I 45N 70 | 67 | 88 | 45 | 70 | Early signal | Oct 28, 2026 |
| 72 | Neuroscience· Notable Perinatal elimination of genetically aberrant human cortical neuronsE 96I 35N 71 | 67 | 96 | 35 | 71 | Early signal | Oct 28, 2026 |
| 73 | Materials & Energy· Notable Altermagnetic signatures and topological textures in ultrathin multiferroic BiFeO3A multiferroic oxide keeps both its electric and magnetic order down to four unit cells E 91I 49N 64 | 66 | 91 | 49 | 64 | Early signal | Oct 28, 2026 |
| 74 | Climate & Environment· Notable Spatial and sectoral water demand assessment for the African continentE 92I 31N 60 | 59 | 92 | 31 | 60 | Early signal | Oct 28, 2026 |
| 75 | Quantum· Notable Probing the memory of a superconducting qubit environmentA qubit's own jumps pick out the defects that make its environment remember its past states E 88I 45N 48 | 56 | 88 | 45 | 48 | Early signal | Oct 28, 2026 |
| 76 | Biomedicine & Health· Notable A three-dimensional human co-culture system reveals reciprocal embryo–endometrial adaptation at implantation onsetE 78I 37N 68 | 62 | 78 | 37 | 68 | Early signal | Oct 27, 2026 |
| 77 | Space & Astronomy· Notable Modeling direct waves in binary black hole ringdownsA proposed way to read a black hole's horizon from merger signals turns out too imprecise to measure it E 88I 53N 57 | 62 | 88 | 53 | 57 | Early signal | Oct 27, 2026 |
| 78 | Neuroscience· Notable Intraventricular clindamycin enhances interstitial brain fluid drainage and the blood–brain barrier after a traumatic brain injuryE 93I 0N 62 | 53 | 93 | 0 | 62 | Early signal | Oct 27, 2026 |
| 79 | Biomedicine & Health· Notable Revised estimates of types and duration of long COVID symptoms based on claims records from 245 million US patientsE 91I 0N 57 | 50 | 91 | 0 | 57 | Early signal | Oct 27, 2026 |
| 80 | Biomedicine & Health· Notable The maternal–fetal interface is an early hematopoietic niche enriched in distinct erythro-myeloid progenitorsE 91I 45N 71 | 67 | 91 | 45 | 71 | Early signal | Oct 26, 2026 |
| 81 | Biomedicine & Health· Notable A CD4-lineage erythro–myeloid progenitor within the adult bone marrow defines an alternative pathway for macrophage generationE 91I 42N 71 | 67 | 91 | 42 | 71 | Early signal | Oct 26, 2026 |
| 82 | Biomedicine & Health· Notable Assessment of comprehensiveness of national cancer control plans using a multiagent artificial intelligence model: a global analysisE 75I 36N 77 | 65 | 75 | 36 | 77 | Early signal | Oct 26, 2026 |
| 83 | Space & Astronomy· Notable A double debris disc around a white dwarf sculpted by two planetary bodiesA white dwarf's gas forms two separate rings, which astronomers propose are fed by two planetary bodies E 90I 30N 68 | 63 | 90 | 30 | 68 | Early signal | Oct 26, 2026 |
| 84 | AI & Computing· Notable Rembrandt through the eyes of the machine: Toward explainable Human–AI collaboration in painting attributionE 89I 0N 81 | 61 | 89 | 0 | 81 | Early signal | Oct 26, 2026 |
| 85 | Biomedicine & Health· Notable A fully marine stem amphibian from the Late Triassic of ChinaE 80I 35N 63 | 59 | 80 | 35 | 63 | Early signal | Oct 26, 2026 |
| 86 | Other frontiers· Notable Changes in American adolescents’ outdoor time over two decadesE 91I 0N 70 | 56 | 91 | 0 | 70 | Early signal | Oct 26, 2026 |
| 87 | Climate & Environment· Notable The scope and severity of bat fatalities at US wind energy facilitiesE 91I 0N 65 | 54 | 91 | 0 | 65 | Early signal | Oct 26, 2026 |
| 88 | AI & Computing· Notable Turing-like tests for language and vision demonstrate a narrowing gap between humans and AIE 91I 0N 65 | 53 | 91 | 0 | 65 | Early signal | Oct 26, 2026 |
| 89 | Biomedicine & Health· Notable Neoadjuvant nivolumab with or without visugromab in muscle-invasive bladder cancer: the phase 2a GDFATHER-NEO trialE 91I 0N 64 | 53 | 91 | 0 | 64 | Early signal | Oct 24, 2026 |
| 90 | Neuroscience· Notable Identification of candidate markers for the isolation of neuron-specific extracellular vesiclesA neuron surface protein, NRXN3, gives a handle for pulling candidate neuron vesicles from blood E 91I 53N 69 | 68 | 91 | 53 | 69 | Early signal | Oct 23, 2026 |
| 91 | Neuroscience· Notable Education reduces dementia incidence and mitigates genetic riskE 93I 37N 69 | 65 | 93 | 37 | 69 | Early signal | Oct 23, 2026 |
| 92 | Biomedicine & Health· Notable Mechanical Thrombectomy 24 to 72 Hours after Large-Vessel Ischemic StrokeE 83I 43N 60 | 59 | 83 | 43 | 60 | Early signal | Oct 23, 2026 |
| 93 | Space & Astronomy· Notable Microquasars as the major contributors to Galactic cosmic rays around the kneeE 86I 60N 49 | 59 | 86 | 60 | 49 | Early signal | Oct 23, 2026 |
| 94 | Biomedicine & Health· Notable Anbenitamab plus HB1801 for HER2-Positive Advanced Breast CancerE 83I 36N 61 | 58 | 83 | 36 | 61 | Early signal | Oct 23, 2026 |
| 95 | AI & Computing· Notable Sequential diagnosis with language modelsA language-model system simulating a panel of physicians correctly diagnosed 83.2% of NEJM case-conference cases in a benchmark, against 36.1% for generalist physicians. E 93I 81N 59 | 71 | 93 | 81 | 59 | Early signal | Oct 22, 2026 |
| 96 | Biomedicine & Health· Notable Steroid hormones produced by coral-associated Endozoicomonas influence coral immune response during thermal stressCoral bacteria make testosterone and progesterone, and giving corals either one shifts their immune genes E 91I 44N 77 | 70 | 91 | 44 | 77 | Early signal | Oct 22, 2026 |
| 97 | Biomedicine & Health· Notable High false sign rates in transcriptome-wide association studiesE 91I 53N 64 | 66 | 91 | 53 | 64 | Early signal | Oct 22, 2026 |
| 98 | Climate & Environment· Notable Late Holocene reexpansion of the Laurentide Ice SheetE 94I 36N 67 | 64 | 94 | 36 | 67 | Early signal | Oct 22, 2026 |
| 99 | Biomedicine & Health· Notable Wireless electrocatalytic closed-loop system for drug-free management of diabesityE 92I 35N 69 | 64 | 92 | 35 | 69 | Early signal | Oct 22, 2026 |
| 100 | Space & Astronomy· Notable The survival paradox of close-in planets orbiting red-clump giantsE 93I 32N 66 | 62 | 93 | 32 | 66 | Early signal | Oct 22, 2026 |
| 101 | Neuroscience· Notable Blinks are strategically coupled with head movements in unconstrained natural gaze behaviorE 91I 0N 67 | 55 | 91 | 0 | 67 | Early signal | Oct 22, 2026 |
| 102 | Neuroscience· Notable Functional architecture of the human insulaE 94I 50N 74 | 70 | 94 | 50 | 74 | Early signal | Oct 21, 2026 |
| 103 | Biomedicine & Health· Notable Cold activates a BH2 metabolic network promoting longevity and proteostasisE 92I 33N 78 | 68 | 92 | 33 | 78 | Early signal | Oct 21, 2026 |
| 104 | Neuroscience· Notable Persistent neuronal stress signalling underlies Angelman syndrome phenotypesE 94I 34N 73 | 66 | 94 | 34 | 73 | Early signal | Oct 21, 2026 |
| 105 | Climate & Environment· Notable The contribution of salt marshes to wave attenuation during extreme stormsE 94I 39N 65 | 64 | 94 | 39 | 65 | Early signal | Oct 21, 2026 |
| 106 | Biomedicine & Health· Notable IL-2-producing TFH cells sustain Treg cell homeostasis and immune tolerance in the gutE 88I 37N 67 | 63 | 88 | 37 | 67 | Early signal | Oct 21, 2026 |
| 107 | Climate & Environment· Notable Amazon carbon emissions driven by human actions amplified by droughtsE 94I 32N 65 | 62 | 94 | 32 | 65 | Early signal | Oct 21, 2026 |
| 108 | Biomedicine & Health· Notable Ianalumab for the Treatment of Patients with Sjögren’s DiseaseE 83I 40N 67 | 62 | 83 | 40 | 67 | Early signal | Oct 21, 2026 |
| 109 | Physics· Notable Octupole-driven spin torque switching of antiferromagnetic tunnel junctionsE 92I 55N 51 | 61 | 92 | 55 | 51 | Early signal | Oct 21, 2026 |
| 110 | Materials & Energy· Notable Additive manufacturing of ultralong and architected single crystalsE 81I 35N 66 | 60 | 81 | 35 | 66 | Early signal | Oct 21, 2026 |
| 111 | Materials & Energy· Notable Touch-sensing digital pixel fibre enables interactive garment GUIE 81I 34N 67 | 60 | 81 | 34 | 67 | Early signal | Oct 21, 2026 |
| 112 | Climate & Environment· Notable Drought and disease trigger novel interactions among top predatorsE 94I 0N 67 | 55 | 94 | 0 | 67 | Early signal | Oct 21, 2026 |
| 113 | Biomedicine & Health· Notable Random, fragile, or correlated: Mechanisms of synteny decay in mammalsE 91I 0N 63 | 52 | 91 | 0 | 63 | Early signal | Oct 21, 2026 |
| 114 | Neuroscience· Notable CX3CL1 (fractalkine)–CX3CR1 interface drives CD8⁺ T cell–induced neurodegeneration in human brain organoidsE 93I 0N 67 | 55 | 93 | 0 | 67 | Early signal | Oct 20, 2026 |
| 115 | Climate & Environment· Notable Disentangling the evolving effects of climate change and technology diffusion on building electricity demandE 91I 0N 63 | 52 | 91 | 0 | 63 | Early signal | Oct 20, 2026 |
| 116 | Materials & Energy· Notable Magnetically guided programmable thermomechanical protection enabled by biomimetic asymmetric designE 91I 0N 63 | 52 | 91 | 0 | 63 | Early signal | Oct 20, 2026 |
| 117 | Biomedicine & Health· Notable Multiancestry conditional and joint analysis applied to GWAS summary statisticsE 91I 0N 61 | 51 | 91 | 0 | 61 | Early signal | Oct 20, 2026 |
| 118 | Climate & Environment· Notable Understory diversity is positively associated with overstory carbon sequestrationE 91I 0N 70 | 55 | 91 | 0 | 70 | Early signal | Oct 19, 2026 |
| 119 | Physics· Notable Quantum correlations and dissipative blockade of polaritons in a tunable fiber cavityE 86I 31N 49 | 52 | 86 | 31 | 49 | Early signal | Oct 19, 2026 |
| 120 | Physics· Notable The extraction of work from hidden degrees of freedomE 88I 48N 63 | 63 | 88 | 48 | 63 | Early signal | Oct 16, 2026 |
| 121 | Quantum· Notable Simultaneous high-fidelity single-qubit gates in a spin qubit arrayE 88I 71N 64 | 69 | 88 | 71 | 64 | Early signal | Oct 15, 2026 |
| 122 | Biomedicine & Health· Notable Airflows redefine the cost of aerial transport in the wildE 81I 37N 73 | 64 | 81 | 37 | 73 | Early signal | Oct 15, 2026 |
| 123 | Biomedicine & Health· Notable A pair of chitosan receptors confer broad-spectrum fungal resistanceE 81I 39N 68 | 62 | 81 | 39 | 68 | Early signal | Oct 15, 2026 |
| 124 | Climate & Environment· Notable Warming-driven lower-tropospheric stratification intensifies ducting over global oceansE 88I 32N 68 | 61 | 88 | 32 | 68 | Early signal | Oct 15, 2026 |
| 125 | Materials & Energy· Notable Modular van der Waals MOSFETs through layer-by-layer chalcogen substitutionsE 81I 32N 64 | 58 | 81 | 32 | 64 | Early signal | Oct 15, 2026 |
| 126 | Biomedicine & Health· Notable De novo design of cysteine proteasesE 91I 64N 70 | 70 | 91 | 64 | 70 | Early signal | Oct 14, 2026 |
| 127 | Other frontiers· Notable Educational intervention can rewire village social networksE 96I 39N 78 | 70 | 96 | 39 | 78 | Early signal | Oct 14, 2026 |
| 128 | Biomedicine & Health· Notable Computational design of metalloproteasesE 93I 54N 71 | 69 | 93 | 54 | 71 | Early signal | Oct 14, 2026 |
| 129 | Biomedicine & Health· Notable Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney InjuryE 96I 39N 71 | 66 | 96 | 39 | 71 | Early signal | Oct 14, 2026 |
| 130 | Neuroscience· Notable Targeted stimulation of motor cortex ensembles drives learned movementsE 94I 49N 64 | 65 | 94 | 49 | 64 | Early signal | Oct 14, 2026 |
| 131 | Biomedicine & Health· Notable Early tetrapod neck mobility modelled using an extant analogueE 96I 39N 66 | 64 | 96 | 39 | 66 | Early signal | Oct 14, 2026 |
| 132 | Biomedicine & Health· Notable Artificial intelligence-enabled clinical phenotyping of human brown fatE 92I 40N 61 | 61 | 92 | 40 | 61 | Early signal | Oct 14, 2026 |
| 133 | Biomedicine & Health· Notable Jurassic flightless bird reveals early ecological diversity of avialansE 94I 35N 62 | 60 | 94 | 35 | 62 | Early signal | Oct 14, 2026 |
| 134 | Biomedicine & Health· Notable Ponatinib–Blinatumomab or Imatinib–Chemotherapy for Adult Ph-Positive ALLE 83I 41N 63 | 60 | 83 | 41 | 63 | Early signal | Oct 14, 2026 |
| 135 | Space & Astronomy· Notable A spatial map of the atmospheric limb of a hot JupiterE 88I 27N 65 | 59 | 88 | 27 | 65 | Early signal | Oct 14, 2026 |
| 136 | Biomedicine & Health· Notable Safety and efficacy of delpacibart zotadirsen in Duchenne muscular dystrophy mutations amenable to exon 44 skipping in the USA (EXPLORE44): a randomised, placebo-controlled, double-blind, phase 1/2 trialE 77I 30N 61 | 55 | 77 | 30 | 61 | Early signal | Oct 14, 2026 |
| 137 | Biomedicine & Health· Notable Effect of Vasopressin Initiation Threshold on Septic Shock MortalityE 93I 0N 63 | 52 | 93 | 0 | 63 | Early signal | Oct 14, 2026 |
| 138 | AI & Computing· Notable Human–artificial intelligence collaboration for comanaging epilepsy in real timeE 93I 48N 73 | 69 | 93 | 48 | 73 | Early signal | Oct 13, 2026 |
| 139 | Space & Astronomy· Notable Two families of multi-planet systems with distinct architectures and stellar hostsE 88I 0N 63 | 51 | 88 | 0 | 63 | Early signal | Oct 13, 2026 |
| 140 | Neuroscience· Notable Heterochronicity shapes brain network formationE 91I 36N 68 | 63 | 91 | 36 | 68 | Early signal | Oct 12, 2026 |
| 141 | AI & Computing· Notable AI-generated language remains systematically distinguishable from human communicationE 91I 52N 56 | 61 | 91 | 52 | 56 | Early signal | Oct 12, 2026 |
| 142 | Biomedicine & Health· Notable In mice, a population of male germ cells show characteristics of nonapoptotic cell death during G0 arrestE 93I 0N 75 | 58 | 93 | 0 | 75 | Early signal | Oct 12, 2026 |
| 143 | Neuroscience· Notable Shedding light on left hippocampal mGlu5 in Alzheimer’s diseaseE 91I 0N 71 | 56 | 91 | 0 | 71 | Early signal | Oct 12, 2026 |
| 144 | Climate & Environment· Notable Field experiments predict ecological response to a large-scale epidemic of an anti-keystone pathogenE 91I 0N 66 | 53 | 91 | 0 | 66 | Early signal | Oct 12, 2026 |
| 145 | Biomedicine & Health· Notable Invasive interval breast cancer rates after digital breast tomosynthesis plus synthesised mammography versus digital mammography screening (TOSYMA): 24-month follow-up of the multicentre, open-label, randomised, controlled, superiority trialE 88I 37N 59 | 58 | 88 | 37 | 59 | Early signal | Oct 9, 2026 |
| 146 | Biomedicine & Health· Notable Interventions to mitigate post-infection morbidity: Management insights from simple modelsE 91I 0N 61 | 51 | 91 | 0 | 61 | Early signal | Oct 9, 2026 |
| 147 | Biomedicine & Health· Notable A DNA Typewriter records the cell lineage history of a mouse, from zygote to late organogenesisE 96I 50N 72 | 69 | 96 | 50 | 72 | Early signal | Oct 8, 2026 |
| 148 | AI & Computing· Notable Tangermeme: a toolkit for understanding cis-regulatory logic using deep learning modelsE 91I 65N 68 | 69 | 91 | 65 | 68 | Early signal | Oct 8, 2026 |
| 149 | AI & Computing· Notable Advancing mathematics research with AI-driven formal proof searchE 91I 85N 52 | 67 | 91 | 85 | 52 | Early signal | Oct 8, 2026 |
| 150 | AI & Computing· Notable Emergence of polarization in networks of large language model agentsSimulated networks of 1,000 LLM agents talking politics drifted into polarized, like-minded camps E 84I 66N 61 | 65 | 84 | 66 | 61 | Early signal | Oct 8, 2026 |
| 151 | AI & Computing· Notable Large language models unlock the ecology of species interactionsE 88I 58N 62 | 64 | 88 | 58 | 62 | Early signal | Oct 8, 2026 |
| 152 | Biomedicine & Health· Notable The genetic basis for the production of toxic quinolizidine alkaloids in lupinsE 81I 43N 72 | 64 | 81 | 43 | 72 | Early signal | Oct 8, 2026 |
| 153 | Space & Astronomy· Notable A fast radio burst at redshift 2, three billion years after the Big BangE 94I 63N 57 | 64 | 94 | 63 | 57 | Early signal | Oct 8, 2026 |
| 154 | Materials & Energy· Notable Gene-driven self-morphing microtubule-based active matterE 91I 27N 66 | 59 | 91 | 27 | 66 | Early signal | Oct 8, 2026 |
| 155 | Biomedicine & Health· Notable Prehistoric global migration of vanishing gut microbes with humansE 94I 50N 75 | 70 | 94 | 50 | 75 | Early signal | Oct 7, 2026 |
| 156 | Physics· Notable A nuclear clock synchronized to 229ThE 94I 65N 65 | 69 | 94 | 65 | 65 | Early signal | Oct 7, 2026 |
| 157 | Physics· Notable A thorium-229 optical nuclear clock with feedback loopE 96I 69N 60 | 67 | 96 | 69 | 60 | Early signal | Oct 7, 2026 |
| 158 | Biomedicine & Health· Notable Human lung organoid modelling of tissue-resident antiviral T cell responsesE 96I 48N 67 | 66 | 96 | 48 | 67 | Early signal | Oct 7, 2026 |
| 159 | AI & Computing· Notable Retrofitting language models to operate over bytesE 94I 58N 62 | 65 | 94 | 58 | 62 | Early signal | Oct 7, 2026 |
| 160 | Materials & Energy· Notable Orthogonal nucleophile-ordered assembly for modular access to enantiopure 1,2-amino alcoholsE 89I 31N 65 | 59 | 89 | 31 | 65 | Early signal | Oct 7, 2026 |
| 161 | Climate & Environment· Notable Australia’s current wildfire crisis linked to colonial land-use changeE 94I 41N 55 | 58 | 94 | 41 | 55 | Early signal | Oct 7, 2026 |
| 162 | Materials & Energy· Notable A 7-eV bandgap semiconductor based on silicon-doped α-(AlxGa1−x)2O3E 81I 26N 64 | 56 | 81 | 26 | 64 | Early signal | Oct 7, 2026 |
| 163 | Neuroscience· Notable Human claustrum neurons encode uncertainty and prediction errors during aversive learningE 91I 35N 66 | 61 | 91 | 35 | 66 | Early signal | Oct 6, 2026 |
| 164 | AI & Computing· Notable Decoding systemic vascular health and hypertensive disorders in pregnancy through retinal imaging and Visionary AIE 91I 0N 78 | 58 | 91 | 0 | 78 | Early signal | Oct 6, 2026 |
| 165 | Space & Astronomy· Notable Discovery of a second-generation planet candidate accreting onto a white dwarfE 90I 34N 66 | 61 | 90 | 34 | 66 | Early signal | Oct 5, 2026 |
| 166 | Climate & Environment· Notable Deep learning of fossil pollen morphology reveals 25,000 y of ecological change in eastern African grasslandsE 91I 36N 72 | 64 | 91 | 36 | 72 | Early signal | Oct 2, 2026 |
| 167 | AI & Computing· Notable An open vision-language model for diverse medical applicationsOpen medical AI models built on Gemma 3 beat their general-purpose base across medical images and text E 91I 96N 64 | 74 | 91 | 96 | 64 | Early signal | Oct 1, 2026 |
| 168 | Biomedicine & Health· Notable Comparative analysis of mitochondrial proteomes across the tree of lifeE 94I 57N 75 | 71 | 94 | 57 | 75 | Early signal | Oct 1, 2026 |
| 169 | Biomedicine & Health· Notable Mitochondrial proteome of Acanthamoeba delineates aerobic and anaerobic pathways dynamically regulated by oxygenE 96I 51N 74 | 70 | 96 | 51 | 74 | Early signal | Oct 1, 2026 |
| 170 | Biomedicine & Health· Notable Comprehensive lineage tracing maps the landscape of cell fate decisions in mouse embryogenesisE 96I 55N 69 | 69 | 96 | 55 | 69 | Early signal | Oct 1, 2026 |
| 171 | Biomedicine & Health· Notable Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cyclingE 94I 47N 68 | 66 | 94 | 47 | 68 | Early signal | Oct 1, 2026 |
| 172 | Biomedicine & Health· Notable A high-confidence plant mitochondrial proteome via protein correlation profilingE 94I 50N 67 | 66 | 94 | 50 | 67 | Early signal | Oct 1, 2026 |
| 173 | Biomedicine & Health· Notable Acanthamoeba ATP synthase structure reveals the TCA cycle is tethered to OXPHOSE 96I 50N 67 | 66 | 96 | 50 | 67 | Early signal | Oct 1, 2026 |
| 174 | Space & Astronomy· Notable Incorporation of atmospheric components in planetary magma oceans through bubble–metal compoundsE 92I 32N 70 | 63 | 92 | 32 | 70 | Early signal | Oct 1, 2026 |
| 175 | AI & Computing· Notable Toward a future space-based, highly scalable AI infrastructure system designE 88I 63N 59 | 63 | 88 | 63 | 59 | Early signal | Oct 1, 2026 |
| 176 | Biomedicine & Health· Notable Loss of the tumor suppressor p53 generates a signaling gradient that drives epithelial clonal expansionE 94I 36N 69 | 63 | 94 | 36 | 69 | Early signal | Oct 1, 2026 |
| 177 | Other frontiers· Notable Defensive networks provide basis for late pre-Hispanic Andean politiesE 91I 34N 65 | 61 | 91 | 34 | 65 | Early signal | Oct 1, 2026 |
| 178 | Biomedicine & Health· Notable Disruption of the Nav1.8/Ankyrin-3 interaction in nociceptors reduces pathological pain-like behaviors in miceE 91I 40N 63 | 61 | 91 | 40 | 63 | Early signal | Oct 1, 2026 |
| 179 | Neuroscience· Notable Selfish and prosocial individuals both distort their actions’ impact, but selfish distortions can be more contagiousE 91I 31N 65 | 60 | 91 | 31 | 65 | Early signal | Oct 1, 2026 |
| 180 | Biomedicine & Health· Notable Oral deucrictibant for on-demand treatment of hereditary angioedema attacks: a phase 3, multicentre, randomised, double-blind, placebo-controlled crossover trialE 93I 41N 55 | 58 | 93 | 41 | 55 | Early signal | Oct 1, 2026 |
| 181 | Neuroscience· Notable Intrinsic rewards guide visual resource allocation via reinforcement learningE 88I 0N 69 | 53 | 88 | 0 | 69 | Early signal | Oct 1, 2026 |
| 182 | Neuroscience· Notable A population code for semantics in human hippocampusE 90I 58N 74 | 69 | 90 | 58 | 74 | Early signal | Sep 30, 2026 |
| 183 | Biomedicine & Health· Notable Butterfly wing patterns in flight create powerful illusory motion cuesE 94I 44N 69 | 65 | 94 | 44 | 69 | Early signal | Sep 30, 2026 |
| 184 | AI & Computing· Notable Scalable decision-making for games of imperfect informationE 94I 54N 62 | 64 | 94 | 54 | 62 | Early signal | Sep 30, 2026 |
| 185 | Biomedicine & Health· Notable Barrier immune memory is programmed by intestinal epithelial cell presentation of cytosol-delivered bacterial antigensE 93I 44N 69 | 64 | 93 | 44 | 69 | Early signal | Sep 30, 2026 |
| 186 | Materials & Energy· Notable X-ray liquidography decodes complex motions in azobenzene isomerizationE 94I 30N 75 | 64 | 94 | 30 | 75 | Early signal | Sep 30, 2026 |
| 187 | Biomedicine & Health· Notable Sugar-rich foods exacerbate antibiotic-induced microbiome disruptionE 96I 49N 63 | 64 | 96 | 49 | 63 | Early signal | Sep 30, 2026 |
| 188 | Biomedicine & Health· Notable Host cell traversal by Plasmodium parasites drives sterilizing T cell-mediated immunity following immunizationE 91I 45N 65 | 63 | 91 | 45 | 65 | Early signal | Sep 30, 2026 |
| 189 | Neuroscience· Notable An amygdala to anterior hypothalamic circuit gates stress sensitivityE 94I 38N 66 | 62 | 94 | 38 | 66 | Early signal | Sep 30, 2026 |
| 190 | Biomedicine & Health· Notable Repeated marine-to-freshwater fish transitions reveal paleoenvironmental modulation of adaptive radiationE 88I 44N 65 | 62 | 88 | 44 | 65 | Early signal | Sep 30, 2026 |
| 191 | AI & Computing· Notable Function-preserving watermarking of AI-generated proteinsE 92I 43N 63 | 61 | 92 | 43 | 63 | Early signal | Sep 30, 2026 |
| 192 | Biomedicine & Health· Notable Osteoclasts intercept meningeal lymphatic paths for dural metastasisE 81I 36N 68 | 60 | 81 | 36 | 68 | Early signal | Sep 30, 2026 |
| 193 | Neuroscience· Notable Prion-like transmission of human tau strains in the mouse brainE 96I 42N 59 | 60 | 96 | 42 | 59 | Early signal | Sep 30, 2026 |
| 194 | Materials & Energy· Notable Wafer-scale epitaxy growth of high-mobility p-type boron carbon nitrideE 89I 32N 61 | 57 | 89 | 32 | 61 | Early signal | Sep 30, 2026 |
| 195 | Neuroscience· Notable Loss of cerebral autoregulation drives abnormal perfusion patterns after strokeE 91I 47N 67 | 64 | 91 | 47 | 67 | Early signal | Sep 29, 2026 |
| 196 | Neuroscience· Notable Comprehensive profiling of brain dynamics during anesthesia across phylogenyE 91I 49N 64 | 63 | 91 | 49 | 64 | Early signal | Sep 29, 2026 |
| 197 | Biomedicine & Health· Notable Phylogeny-agnostic strain-level prediction of phage–host interactions from genomes using machine learningE 91I 48N 63 | 62 | 91 | 48 | 63 | Early signal | Sep 29, 2026 |
| 198 | Biomedicine & Health· Notable Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of ObesityE 85I 54N 60 | 61 | 85 | 54 | 60 | Early signal | Sep 29, 2026 |
| 199 | Quantum· Notable Twisted Rényi negativity as a reliable proxy for mixed-state entanglement in fermionic systemsE 91I 41N 63 | 61 | 91 | 41 | 63 | Early signal | Sep 29, 2026 |
| 200 | Space & Astronomy· Notable Growth of aromatic hydrocarbon dust particles in the extremely metal-poor galaxy Sextans AE 88I 50N 61 | 61 | 88 | 50 | 61 | Early signal | Sep 29, 2026 |
| 201 | Biomedicine & Health· Notable Retatrutide in adults with obesity and type 2 diabetes (TRIUMPH-2): a double-blind, parallel-group, randomised, placebo-controlled, phase 3 trialE 82I 49N 58 | 59 | 82 | 49 | 58 | Early signal | Sep 29, 2026 |
| 202 | Biomedicine & Health· Notable Werner helicase inhibitor for advanced microsatellite instability solid tumors: a phase 1 trialE 91I 44N 58 | 59 | 91 | 44 | 58 | Early signal | Sep 29, 2026 |
| 203 | Neuroscience· Notable Functional brain networks underlying approach–avoidance conflict processing in humans and ratsE 91I 31N 65 | 59 | 91 | 31 | 65 | Early signal | Sep 29, 2026 |
| 204 | Biomedicine & Health· Notable Phosphoproteomic dysregulation promotes tumor proliferation in Cushing’s diseaseE 93I 0N 65 | 52 | 93 | 0 | 65 | Early signal | Sep 29, 2026 |
| 205 | Physics· Notable Multiscale transitional flow in anisotropic nanoparticle suspensions revealed by time-resolved X-ray scatter microscopyE 88I 30N 50 | 51 | 88 | 30 | 50 | Early signal | Sep 29, 2026 |
| 206 | Biomedicine & Health· Notable The Mader model of muscle energy metabolism simulates key metabolic exercise phenomenaE 91I 43N 65 | 62 | 91 | 43 | 65 | Early signal | Sep 28, 2026 |
| 207 | Other frontiers· Notable Continuous UV irradiation played an inconclusive role in selecting the canonical genetic alphabetE 91I 29N 72 | 62 | 91 | 29 | 72 | Early signal | Sep 28, 2026 |
| 208 | Biomedicine & Health· Notable Mechanical stress remodelling drives epithelial–mesenchymal transition in the tumour microenvironmentE 93I 32N 68 | 61 | 93 | 32 | 68 | Early signal | Sep 28, 2026 |
| 209 | Climate & Environment· Notable Regional climate risk assessment from climate models using probabilistic machine learningE 88I 58N 53 | 59 | 88 | 58 | 53 | Early signal | Sep 28, 2026 |
| 210 | Climate & Environment· Notable Uneven attention to climate tipping pointsE 91I 27N 66 | 59 | 91 | 27 | 66 | Early signal | Sep 28, 2026 |
| 211 | AI & Computing· Notable Large-scale semidefinite programming with graphics processing unitsE 91I 29N 63 | 58 | 91 | 29 | 63 | Early signal | Sep 28, 2026 |
| 212 | Materials & Energy· Notable Phototropic and skototropic growth in inorganic filmsE 91I 0N 74 | 56 | 91 | 0 | 74 | Early signal | Sep 28, 2026 |
| 213 | Quantum· Notable Aharonov–Bohm interference in a Z2 lattice gauge theory on a hybrid qubit–oscillator quantum computerE 91I 65N 68 | 68 | 91 | 65 | 68 | Early signal | Sep 25, 2026 |
| 214 | Biomedicine & Health· Notable Systematic mapping of bacteriophage gene essentiality with HIDEN-SEQE 91I 50N 67 | 65 | 91 | 50 | 67 | Early signal | Sep 25, 2026 |
| 215 | Biomedicine & Health· Notable Rapid genome-wide purging following tsunami-induced hybridization in a stickleback populationE 91I 40N 67 | 62 | 91 | 40 | 67 | Early signal | Sep 25, 2026 |
| 216 | Physics· Notable Transient chaos in the self-organization of dissipative optical solitonsE 91I 0N 69 | 53 | 91 | 0 | 69 | Early signal | Sep 25, 2026 |
| 217 | Biomedicine & Health· Notable Ecdysteroid signaling acts as a central switch underlying wing polyphenism in two hemipteran insectsE 91I 0N 65 | 52 | 91 | 0 | 65 | Early signal | Sep 25, 2026 |
| 218 | Neuroscience· Notable Dynamic attribute activation explains gaze biases in choiceE 91I 0N 67 | 52 | 91 | 0 | 67 | Early signal | Sep 25, 2026 |
| 219 | Climate & Environment· Notable Rewriting the history of the invasive spiny water flea in North AmericaE 91I 34N 67 | 60 | 91 | 34 | 67 | Early signal | Sep 24, 2026 |
| 220 | Biomedicine & Health· Notable A transcription factor regulates development of a bacteria-housing eukaryotic cell through DNA damage mitigationE 91I 0N 75 | 56 | 91 | 0 | 75 | Early signal | Sep 24, 2026 |
| 221 | Climate & Environment· Notable Public support for novel carbon removal hinges on procedural and distributive fairnessE 91I 0N 55 | 47 | 91 | 0 | 55 | Early signal | Sep 24, 2026 |
| 222 | Neuroscience· Notable Lifespan single-cell transcriptomic atlas of the human prefrontal cortexE 96I 56N 72 | 69 | 96 | 56 | 72 | Early signal | Sep 23, 2026 |
| 223 | Climate & Environment· Notable The anthropogenic fingerprint on emerging infectious diseasesE 94I 62N 71 | 69 | 94 | 62 | 71 | Early signal | Sep 23, 2026 |
| 224 | Climate & Environment· Notable Agricultural liming is a carbon sink in the Mississippi River BasinE 94I 47N 76 | 69 | 94 | 47 | 76 | Early signal | Sep 23, 2026 |
| 225 | Quantum· Notable String-breaking dynamics in a quantum simulatorE 88I 69N 66 | 67 | 88 | 69 | 66 | Early signal | Sep 23, 2026 |
| 226 | Neuroscience· Notable The lipidomic architecture of the mouse brainE 94I 59N 66 | 66 | 94 | 59 | 66 | Early signal | Sep 23, 2026 |
| 227 | Neuroscience· Notable Ultrafast venous and sagittal sinus constrictions in the brain driven by abdominal pressureE 93I 49N 71 | 66 | 93 | 49 | 71 | Early signal | Sep 23, 2026 |
| 228 | Biomedicine & Health· Notable Efficient differential expression analysis of large-scale single-cell transcriptomics data using DreamletE 89I 69N 63 | 66 | 89 | 69 | 63 | Early signal | Sep 23, 2026 |
| 229 | Neuroscience· Major Single-cell atlas of transcriptomic vulnerability across brain disordersE 96I 51N 69 | 66 | 96 | 51 | 69 | Firming up | Sep 23, 2026 |
| 230 | Physics· Notable Gravitational torque drives multidecadal variations in length of dayE 94I 43N 72 | 66 | 94 | 43 | 72 | Early signal | Sep 23, 2026 |
| 231 | Neuroscience· Notable Single-nucleus transcriptome-wide association study of human brain disordersE 96I 51N 66 | 65 | 96 | 51 | 66 | Early signal | Sep 23, 2026 |
| 232 | Biomedicine & Health· Major Reference genomes and fossils revise bat family phylogeny and biogeographyE 97I 51N 64 | 64 | 97 | 51 | 64 | Firming up | Sep 23, 2026 |
| 233 | Neuroscience· Notable Single-nucleus atlas of cell-type specific genetic regulation in the human brainE 93I 50N 65 | 64 | 93 | 50 | 65 | Early signal | Sep 23, 2026 |
| 234 | Biomedicine & Health· Notable Lsp2 links early-life diet to adult translation and lifespan in DrosophilaE 94I 46N 67 | 64 | 94 | 46 | 67 | Early signal | Sep 23, 2026 |
| 235 | Physics· Notable Lu+ optical frequency references with accuracy verified at the 19th digitE 96I 50N 61 | 62 | 96 | 50 | 61 | Early signal | Sep 23, 2026 |
| 236 | Materials & Energy· Notable An open-framework boron allotrope exhibiting high conductivity and plasticityE 89I 28N 63 | 57 | 89 | 28 | 63 | Early signal | Sep 23, 2026 |
| 237 | Biomedicine & Health· Major Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer DiagnosisE 97I 56N 62 | 65 | 97 | 56 | 62 | Firming up | Sep 22, 2026 |
| 238 | Biomedicine & Health· Notable Structural diversification of phage tail fibers enables recognition of diverse type IV piliE 88I 40N 68 | 61 | 88 | 40 | 68 | Early signal | Sep 22, 2026 |
| 239 | Neuroscience· Notable System-level synchronization and subtype-specific modules govern brain-wide serotonin axon innervationE 91I 0N 73 | 55 | 91 | 0 | 73 | Early signal | Sep 22, 2026 |
| 240 | Space & Astronomy· Notable Meteoritic organic matter records primitive oxygen reservoirs of the solar systemE 91I 0N 70 | 54 | 91 | 0 | 70 | Early signal | Sep 21, 2026 |
| 241 | Other frontiers· Notable Bistability of compartmentalized autocatalytic systems at the dawn of hereditary variationE 91I 0N 67 | 52 | 91 | 0 | 67 | Early signal | Sep 21, 2026 |
| 242 | Physics· Notable Zinc isotopic evidence for an Archean initiation of deep carbon cyclingE 91I 0N 64 | 50 | 91 | 0 | 64 | Early signal | Sep 18, 2026 |
| 243 | Physics· Notable Disorder-promoted stabilityE 91I 47N 70 | 64 | 91 | 47 | 70 | Early signal | Sep 17, 2026 |
| 244 | AI & Computing· Notable Reimagining research papers as interactive and reliable AI agentsE 94I 68N 76 | 73 | 94 | 68 | 76 | Early signal | Sep 16, 2026 |
| 245 | Biomedicine & Health· Notable Developmental xenocortication using human-derived organoids in miceE 94I 52N 67 | 65 | 94 | 52 | 67 | Early signal | Sep 16, 2026 |
| 246 | Biomedicine & Health· Notable Molecular-level observation of the self-assembly of a virus-like particleE 94I 39N 71 | 63 | 94 | 39 | 71 | Early signal | Sep 16, 2026 |
| 247 | Neuroscience· Notable Intracranial recordings in humans reveal differential contributions of medial and lateral orbitofrontal cortex to approach–avoidance decision-makingE 91I 44N 64 | 61 | 91 | 44 | 64 | Early signal | Sep 15, 2026 |
| 248 | Materials & Energy· Notable Disentangling the effect of space and electric field on photoelectrochemical water splittingE 87I 0N 60 | 47 | 87 | 0 | 60 | Early signal | Sep 12, 2026 |
| 249 | Materials & Energy· Notable Catalytic Asymmetric Spiroannulation to Access Polycyclic Spiro Enones via Transient Axial-to-Point Chirality Induction and TransferE 87I 0N 52 | 44 | 87 | 0 | 52 | Early signal | Sep 12, 2026 |
| 250 | Biomedicine & Health· Notable Cancer treatment alters mutant selection in normal esophagusE 91I 40N 69 | 62 | 91 | 40 | 69 | Early signal | Sep 11, 2026 |
| 251 | Biomedicine & Health· Notable Formin-1 maintains cochlear microtubule architecture required for hearing in humans and miceE 93I 37N 66 | 60 | 93 | 37 | 66 | Early signal | Sep 11, 2026 |
| 252 | Materials & Energy· Notable Imaging the Meissner effect in lanthanum hydride using diamond quantum sensorsE 91I 47N 60 | 59 | 91 | 47 | 60 | Early signal | Sep 11, 2026 |
| 253 | Climate & Environment· Notable Compound and heterogeneous relationships between climate extremes and global net migrationE 91I 29N 63 | 57 | 91 | 29 | 63 | Early signal | Sep 11, 2026 |
| 254 | Climate & Environment· Notable Divergence between physical and emotional heat resilience in Chinese citiesE 88I 26N 62 | 55 | 88 | 26 | 62 | Early signal | Sep 11, 2026 |
| 255 | Climate & Environment· Notable Evolution of flowering phenology over 44 years of climate changeE 91I 0N 68 | 52 | 91 | 0 | 68 | Early signal | Sep 11, 2026 |
| 256 | Biomedicine & Health· Notable Multicellular rosette formation guides epithelial tissue assembly in pancreatic ductal adenocarcinoma cell organoidsE 91I 0N 65 | 51 | 91 | 0 | 65 | Early signal | Sep 11, 2026 |
| 257 | Neuroscience· Notable Facial palsy reveals the sensorimotor contribution to facial-emotion recognitionE 91I 0N 63 | 50 | 91 | 0 | 63 | Early signal | Sep 11, 2026 |
| 258 | Neuroscience· Notable Identifiability of Bayesian models of perceptionE 91I 0N 58 | 48 | 91 | 0 | 58 | Early signal | Sep 11, 2026 |
| 259 | Physics· Notable Discovery of an intrinsic non-Hermitian phase transition in a bulk condensed-matter systemE 94I 47N 68 | 64 | 94 | 47 | 68 | Early signal | Sep 10, 2026 |
| 260 | Biomedicine & Health· Notable Phenomic profiles and disease patterns of 1.9 million participants from Our Future HealthE 91I 38N 67 | 60 | 91 | 38 | 67 | Early signal | Sep 10, 2026 |
| 261 | AI & Computing· Notable A clinically-oriented foundation model for intraoperative pathologyE 89I 27N 66 | 57 | 89 | 27 | 66 | Early signal | Sep 10, 2026 |
| 262 | Biomedicine & Health· Notable TM184C is a GPCR-like regulator of intercellular exchange and autophagyE 96I 35N 69 | 62 | 96 | 35 | 69 | Early signal | Sep 9, 2026 |
| 263 | Other frontiers· Notable Ancient proteins identify various Denisovan remains from Southwest ChinaE 94I 47N 62 | 60 | 94 | 47 | 62 | Early signal | Sep 9, 2026 |
| 264 | Climate & Environment· Notable Seasonally asymmetric warming reshapes grassland stability across timescalesE 91I 0N 66 | 51 | 91 | 0 | 66 | Early signal | Sep 9, 2026 |
| 265 | AI & Computing· Notable Plausible nonsense and deliberative reasoning: Benchmarking LLMs against human judgmentE 91I 0N 58 | 47 | 91 | 0 | 58 | Early signal | Sep 9, 2026 |
| 266 | Biomedicine & Health· Major MemBrain v2: an end-to-end tool for the analysis of membranes in cryo-electron tomographyE 88I 93N 71 | 74 | 88 | 93 | 71 | Firming up | Sep 8, 2026 |
| 267 | Space & Astronomy· Major Planetary shielding and surface precipitation of solar energetic particles during BepiColombo’s close Mercury flybyE 93I 36N 68 | 60 | 93 | 36 | 68 | Firming up | Sep 8, 2026 |
| 268 | Climate & Environment· Notable Scale-dependent effects of species richness and asynchrony regulate the temporal stability of consumer-mediated nutrient dynamicsE 91I 35N 68 | 60 | 91 | 35 | 68 | Early signal | Sep 8, 2026 |
| 269 | Other frontiers· Notable Heel-strike mechanics reveal evolutionary trade-offs in hominin bipedalismE 91I 0N 73 | 54 | 91 | 0 | 73 | Early signal | Sep 8, 2026 |
| 270 | Biomedicine & Health· Major Deconstruction of lysergic acid diethylamideE 94I 0N 64 | 51 | 94 | 0 | 64 | Firming up | Sep 8, 2026 |
| 271 | Climate & Environment· Notable Increasing risk of vapor pressure deficit exceeding critical thresholds for tree growthE 91I 0N 61 | 48 | 91 | 0 | 61 | Early signal | Sep 8, 2026 |
| 272 | Materials & Energy· Notable Operando electrochemiluminescence imaging of intermediate evolution and kinetics in electrocatalytic nitrate reductionE 87I 0N 49 | 42 | 87 | 0 | 49 | Early signal | Sep 5, 2026 |
| 273 | AI & Computing· Notable Explainable deep learning improves human mental models of self-driving carsE 94I 49N 62 | 60 | 94 | 49 | 62 | Early signal | Sep 2, 2026 |
| 274 | Biomedicine & Health· Notable Cohesin prevents local mixing of condensed euchromatic domains in living human cellsE 91I 52N 79 | 69 | 91 | 52 | 79 | Early signal | Sep 1, 2026 |
| 275 | Neuroscience· Major Sexual dimorphism in the complete Drosophila male central nervous system connectomeThe first complete male fruit fly nervous system, brain and nerve cord, at synaptic resolution E 97I 76N 67 | 69 | 97 | 76 | 67 | Firming up | Sep 1, 2026 |
| 276 | AI & Computing· Notable Clinical usability of an explainable AI decision support tool and evaluation of multimodal models in NSCLCE 91I 44N 59 | 58 | 91 | 44 | 59 | Early signal | Sep 1, 2026 |
| 277 | Biomedicine & Health· Notable Predicting cellular responses to perturbation across diverse contexts with StateState predicts how cells' gene expression responds to perturbation, and flags strong perturbations in cellular contexts where it saw none in training. E 94I 75N 67 | 69 | 94 | 75 | 67 | Early signal | Aug 31, 2026 |
| 278 | Neuroscience· Notable What one sees depends on how far the eye has movedE 89I 37N 88 | 68 | 89 | 37 | 88 | Early signal | Aug 30, 2026 |
| 279 | Materials & Energy· Notable Coupled spin-coordination self-adaptation drives efficient nitrate to ammonia conversionE 87I 0N 54 | 44 | 87 | 0 | 54 | Early signal | Aug 29, 2026 |
| 280 | AI & Computing· Notable BeyondMimic: From motion tracking to versatile humanoid control via guided diffusionOne training recipe gives a humanoid cartwheels, spin kicks and sprinting, and one distilled model handles new tasks E 86I 92N 64 | 68 | 86 | 92 | 64 | Early signal | Aug 26, 2026 |
| 281 | Neuroscience· Notable A cortical output channel for perceptual categorizationOnly one deep-layer cortical output cell type gains categorical responses as mice learn to categorize sounds E 86I 59N 60 | 59 | 86 | 59 | 60 | Early signal | Aug 26, 2026 |
| 282 | Materials & Energy· Notable Electronic and solvent reorganization in proton-coupled electron transfer captured by ultrafast X-raysUltrafast X-rays resolve the electron, proton, and solvent steps of proton-coupled electron transfer in water E 87I 43N 64 | 58 | 87 | 43 | 64 | Early signal | Aug 26, 2026 |
| 283 | Physics· Notable 3D bulk-resolved g-wave altermagnetic order parameter in CrSbMagnetic quantum oscillations resolve the g-wave order parameter of the altermagnet CrSb in 3D E 94I 57N 51 | 57 | 94 | 57 | 51 | Early signal | Aug 26, 2026 |
| 284 | Neuroscience· Notable An axon-intrinsic loop restricts nerve regeneration through axonal protein synthesisA REG3A-to-KHSRP axonal loop brakes peripheral nerve regeneration through localized mRNA translation E 89I 0N 64 | 49 | 89 | 0 | 64 | Early signal | Aug 26, 2026 |
| 285 | Space & Astronomy· Notable A gas-enshrouded and gas-reddened black hole at cosmic dawnA black hole 660 million years after the Big Bang appears wrapped in dense gas that reddens its light E 96I 79N 57 | 64 | 96 | 79 | 57 | Early signal | Aug 12, 2026 |
| 286 | Biomedicine & Health· Major A complete diploid human genome benchmark for personalized genomicsA telomere-to-telomere HG002 benchmark covering the diploid genome's hardest regions E 96I 72N 61 | 63 | 96 | 72 | 61 | Firming up | Aug 1, 2026 |
| 287 | Neuroscience· Notable Noninvasive decoding of typed sentences from human brain activityA model reads typed sentences off magnetic recordings of the brain, with no implant E 91I 70N 60 | 59 | 91 | 70 | 60 | Early signal | Jun 29, 2026 |
| 288 | Quantum· Notable Helios: a 98-qubit trapped-ion machine that stays accurate as it scalesQuantinuum reaches beyond-classical circuits without giving up the field's best gate fidelity. E 94I 79N 62 | 61 | 94 | 79 | 62 | Early signal | Jun 17, 2026 |
| 289 | Neuroscience· Major Distributed control circuits across a brain-and-cord connectomeFirst adult fruit fly connectome joining brain and ventral nerve cord E 97I 75N 67 | 62 | 97 | 75 | 67 | Firming up | Jun 8, 2026 |
| 290 | Neuroscience· Major Neuropixels Opto: combining high-resolution electrophysiology and optogeneticsNeuropixels probe fusing 960 recording sites with on-shank optogenetic light emitters E 93I 60N 62 | 56 | 93 | 60 | 62 | Firming up | Jun 1, 2026 |
| 291 | Biomedicine & Health· Notable Efficient base editing and development in human embryos without chromosomal alterationsE 77I 19N 59 | 44 | 77 | 19 | 59 | Early signal | Jun 1, 2026 |
| 292 | Biomedicine & Health· Major Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic CancerE 85I 87N 53 | 56 | 85 | 87 | 53 | Firming up | May 31, 2026 |
| 293 | Biomedicine & Health· Major A Single Base-Editing Infusion Cuts LDL Cholesterol Up to 62%In vivo editing of the PCSK9 gene produced durable cholesterol reductions in an early-stage trial. E 97I 70N 71 | 63 | 97 | 70 | 71 | Firming up | May 25, 2026 |
| 294 | AI & Computing· Major Accelerating scientific discovery with Co-ScientistA multi-agent AI system on Gemini that generates and validates scientific hypotheses E 94I 93N 72 | 66 | 94 | 93 | 72 | Firming up | May 19, 2026 |
| 295 | Biomedicine & Health· Major Large-scale discovery, analysis and design of protein energy landscapesMass spec measures fluctuation energies for 5,778 protein domains in parallel E 96I 63N 63 | 57 | 96 | 63 | 63 | Firming up | May 13, 2026 |
| 296 | Materials & Energy· Notable 4D printing of hierarchically porous carbon–supported high-entropy ceramic metamaterial for tunable microwave absorptionA 4D-printed metamaterial absorber that reshapes on heating to retune its radar-band absorption E 87I 70N 44 | 49 | 87 | 70 | 44 | Firming up | May 13, 2026 |
| 297 | Biomedicine & Health· Major Ancient DNA reveals pervasive directional selection across West EurasiaAncient-DNA time series reveal hundreds of alleles under directional selection in humans E 97I 70N 57 | 55 | 97 | 70 | 57 | Firming up | Apr 15, 2026 |
| 298 | Biomedicine & Health· Major Base-Edited Stem Cells Switch On Fetal Hemoglobin to Treat Sickle CellA precise single-letter edit reawakens protective fetal hemoglobin without cutting DNA. E 85I 69N 60 | 52 | 85 | 69 | 60 | Firming up | Apr 1, 2026 |
| 299 | Biomedicine & Health· Major Evo 2: a genome foundation model across all of lifeNine trillion base pairs of training, a megabase of context, single-nucleotide resolution. E 97I 92N 59 | 57 | 97 | 92 | 59 | Settled | Mar 4, 2026 |
| 300 | Biomedicine & Health· Major Bimagrumab plus semaglutide alone or in combination for the treatment of obesity: a randomized phase 2 trialBimagrumab plus semaglutide produced greater weight loss than either drug alone in a phase 2 trial E 94I 81N 48 | 50 | 94 | 81 | 48 | Settled | Mar 1, 2026 |
| 301 | Climate & Environment· Notable MethaneSAT Maps the World's Oil and Gas Methane Super-EmittersA dedicated satellite resolves individual leaking sites across the planet's biggest fossil-fuel basins. E 88I 52N 49 | 44 | 88 | 52 | 49 | Firming up | Feb 26, 2026 |
| 302 | Neuroscience· Major Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s diseaseSingle-cell multiomic profiling maps hippocampal neurogenesis across ageing and Alzheimer's disease E 96I 73N 57 | 52 | 96 | 73 | 57 | Firming up | Feb 25, 2026 |
| 303 | Biomedicine & Health· Major Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBCAfter a personalized neoantigen mRNA vaccine, 11 of 14 TNBC patients stayed relapse-free for up to six years E 96I 71N 59 | 52 | 96 | 71 | 59 | Firming up | Feb 18, 2026 |
| 304 | Materials & Energy· Notable A self-powered hydrogel electronic skin with decoupled multimodal sensing for closed-loop human-machine interactionsE 87I 71N 45 | 45 | 87 | 71 | 45 | Firming up | Feb 12, 2026 |
| 305 | Climate & Environment· Notable A Cloud-Feedback Constraint That Points Climate Sensitivity HigherLinking tropical cloud change to ocean warming patterns halves the field's biggest uncertainty. E 88I 32N 55 | 41 | 88 | 32 | 55 | Firming up | Feb 2, 2026 |
| 306 | Space & Astronomy· Notable JWST Confirms MoM-z14, a Galaxy Seen 280 Million Years After the Big BangThe most distant galaxy yet confirmed deepens the puzzle of early bright galaxies. E 90I 81N 41 | 46 | 90 | 81 | 41 | Firming up | Jan 30, 2026 |
| 307 | Biomedicine & Health· Major AlphaGenome Reads a Megabase of DNA at Single-Base ResolutionOne model predicts thousands of regulatory genomic tracks and tops specialist tools on variant effects. E 96I 93N 53 | 53 | 96 | 93 | 53 | Settled | Jan 28, 2026 |
| 308 | Climate & Environment· Notable Pesticide residues alter taxonomic and functional biodiversity in soilsPesticide residues rank as the second strongest driver of soil biodiversity across European soils E 92I 75N 52 | 49 | 92 | 75 | 52 | Firming up | Jan 28, 2026 |
| 309 | Neuroscience· Notable The glymphatic system clears amyloid beta and tau from brain to plasma in humansNormal sleep raises plasma amyloid beta and tau versus sleep deprivation in a randomized crossover trial E 89I 77N 49 | 48 | 89 | 77 | 49 | Settled | Jan 27, 2026 |
| 310 | Climate & Environment· Notable Permafrost Thaw and Arctic Fires Shrink the Paris Carbon BudgetAdding two feedbacks that models usually ignore cuts the room left under 1.5 C by a quarter. E 88I 48N 55 | 44 | 88 | 48 | 55 | Firming up | Jan 24, 2026 |
| 311 | Biomedicine & Health· Notable Nanoparticles hijack calvarial immune cells for CNS drug delivery and stroke therapyDrug-loaded nanoparticles hijack skull immune cells to bypass the blood-brain barrier for stroke therapy E 92I 69N 51 | 47 | 92 | 69 | 51 | Firming up | Jan 16, 2026 |
| 312 | Space & Astronomy· Notable JWST's 'Little Red Dots' Are Young Black Holes in Glowing CocoonsElectron-scattering line shapes cut estimated black-hole masses about a hundredfold. E 96I 79N 49 | 48 | 96 | 79 | 49 | Settled | Jan 14, 2026 |
| 313 | Biomedicine & Health· Notable Mapping somatosensory afferent circuitry to bone identifies neurotrophic signals required for fracture healingA single-cell map of bone-innervating sensory neurons identifies FGF9 as a driver of fracture repair E 93I 71N 54 | 48 | 93 | 71 | 54 | Settled | Jan 8, 2026 |
| 314 | Biomedicine & Health· Notable An Immune Map of a Pig Kidney in a Living PersonHigh-dimensional profiling reveals how a gene-edited pig organ is rejected, and how it holds. E 93I 69N 47 | 45 | 93 | 69 | 47 | Firming up | Jan 1, 2026 |
| 315 | Materials & Energy· Notable Limiting phosphonic acid interlayer–perovskite reactivity to stabilize perovskite solar modulesA strongly binding phosphonic acid interlayer gives perovskite cells a T90 of nearly 3000 hours at 85°C E 91I 74N 42 | 44 | 91 | 74 | 42 | Settled | Jan 1, 2026 |
| 316 | AI & Computing· Notable AI-enabled virtual spatial proteomics from histopathology for interpretable biomarker discovery in lung cancerAn AI model generates spatial proteomics from H&E slides to improve lung cancer prognostic accuracy E 93I 74N 42 | 44 | 93 | 74 | 42 | Settled | Jan 1, 2026 |
| 317 | Physics· Emerging EAST Tokamak Runs Stably Past the Greenwald Density LimitA Chinese fusion device holds plasma densities up to 65% above a barrier long thought to trigger disruption. E 89I 39N 45 | 38 | 89 | 39 | 45 | Firming up | Jan 1, 2026 |
| 318 | Biomedicine & Health· Major Mapping the genetic landscape across 14 psychiatric disordersFive genomic factors explain most shared genetic risk across 14 psychiatric disorders E 96I 82N 58 | 51 | 96 | 82 | 58 | Settled | Dec 10, 2025 |
| 319 | Biomedicine & Health· Major RFdiffusion2 Designs Enzymes Directly From Catalytic GeometryA generative model scaffolds enzyme active sites from functional-group positions alone, no residue order required. E 91I 78N 65 | 51 | 91 | 78 | 65 | Settled | Dec 3, 2025 |
| 320 | Biomedicine & Health· Notable Designing Zinc Enzymes from Scratch That Rival Nature's Catalytic SpeedA generative model builds active metallohydrolases straight from chemistry, no lab tinkering required. E 94I 73N 60 | 49 | 94 | 73 | 60 | Settled | Dec 3, 2025 |
| 321 | Space & Astronomy· Notable Bennu's Grains Carry the Building Blocks of LifeReturned asteroid samples hold nucleobases, amino acids, and a first hint of tryptophan. E 91I 66N 54 | 45 | 91 | 66 | 54 | Firming up | Nov 24, 2025 |
| 322 | Biomedicine & Health· Notable A skin-permeable polymer for non-invasive transdermal insulin deliveryE 94I 69N 51 | 45 | 94 | 69 | 51 | Settled | Nov 19, 2025 |
| 323 | Neuroscience· Notable Deep-Brain Stimulation Finds a Signal That Predicts Who Beats DepressionAn intracranial biomarker forecasts response to BNST-NAc stimulation for treatment-refractory depression. E 89I 56N 46 | 40 | 89 | 56 | 46 | Firming up | Nov 18, 2025 |