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AI & Computing

Latest AI Breakthroughs

Machine learning, foundation models, algorithms, and the systems that run them. Every AI & Computing result in the index, its impact anchored on work of its own field and year, ranked by Frontier Score.

Top of the field · Notable

An open vision-language model for diverse medical applications

Open medical AI models built on Gemma 3 beat their general-purpose base across medical images and text

74/ 100

Evidence 91Impact 96Novelty 64

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Every AI & Computing breakthrough

Ranked by live Frontier Score. Search, filter by date, or sort by any pillar.

39 breakthroughs
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Since
#
01
AI & Computing· Notable
An open vision-language model for diverse medical applications
E 91I 96N 64
74
02
AI & Computing· Notable
Generating interesting scientific ideas using knowledge graphs and LLMs: Evaluations with 100 research group leaders
E 88I 63N 72
73
03
AI & Computing· Notable
Reimagining research papers as interactive and reliable AI agents
E 94I 69N 75
72
04
AI & Computing· Notable
Intrinsically motivated humans and agents in open-world exploration
E 91I 57N 71
71
05
AI & Computing· Notable
Sequential diagnosis with language models
E 93I 81N 59
71
06
AI & Computing· Notable
Human–artificial intelligence collaboration for comanaging epilepsy in real time
E 93I 48N 73
69
07
AI & Computing· Notable
Tangermeme: a toolkit for understanding cis-regulatory logic using deep learning models
E 91I 65N 68
69
08
AI & Computing· Notable
BeyondMimic: From motion tracking to versatile humanoid control via guided diffusion
E 86I 92N 63
68
09
AI & Computing· Notable
Advancing mathematics research with AI-driven formal proof search
E 91I 85N 52
67
10
AI & Computing· Notable
Emergence of polarization in networks of large language model agents
E 87I 68N 61
66
11
AI & Computing· Major
Accelerating scientific discovery with Co-Scientist
E 94I 93N 72
66
12
AI & Computing· Notable
Retrofitting language models to operate over bytes
E 94I 58N 62
65
13
AI & Computing· Notable
Denoising the US Census: Succinct block hierarchical regression
E 89I 49N 62
64
14
AI & Computing· Notable
Foundation model for particle collision data analysis
E 88I 52N 60
64
15
AI & Computing· Notable
Large language models unlock the ecology of species interactions
E 88I 58N 62
64
16
AI & Computing· Notable
Toward a future space-based, highly scalable AI infrastructure system design
E 88I 63N 59
63
17
AI & Computing· Notable
Scalable decision-making for games of imperfect information
E 94I 54N 62
63
18
AI & Computing· Notable
Rembrandt through the eyes of the machine: Toward explainable Human–AI collaboration in painting attribution
E 89I 0N 81
61
19
AI & Computing· Notable
AI-generated language remains systematically distinguishable from human communication
E 91I 52N 56
61
20
AI & Computing· Notable
Function-preserving watermarking of AI-generated proteins
E 92I 43N 63
61
21
AI & Computing· Notable
Explainable deep learning improves human mental models of self-driving cars
E 94I 49N 62
60
22
AI & Computing· Notable
Decoding systemic vascular health and hypertensive disorders in pregnancy through retinal imaging and Visionary AI
E 91I 0N 78
58
23
AI & Computing· Notable
Large-scale semidefinite programming with graphics processing units
E 91I 33N 63
58
24
AI & Computing· Notable
Clinical usability of an explainable AI decision support tool and evaluation of multimodal models in NSCLC
E 91I 44N 59
58
25
AI & Computing· Notable
A clinically-oriented foundation model for intraoperative pathology
E 89I 27N 66
57
26
AI & Computing· Notable
Turing-like tests for language and vision demonstrate a narrowing gap between humans and AI
E 91I 0N 65
53
27
AI & Computing· Major
Kolmogorov-Arnold Networks Meet Science
E 85I 97N 64
51
28
AI & Computing· Major
AlphaProof reaches silver-medal level at the Math Olympiad
E 96I 82N 59
50
29
AI & Computing· Notable
Plausible nonsense and deliberative reasoning: Benchmarking LLMs against human judgment
E 91I 0N 58
47
30
AI & Computing· Notable
A multimodal whole-slide foundation model for pathology
E 94I 85N 49
47
31
AI & Computing· Notable
Delphi-2M: A Generative Transformer for Lifetime Disease Risk
E 91I 84N 57
47
32
AI & Computing· Notable
DeepSeek-R1: reasoning learned through pure reinforcement learning
E 97I 100N 43
46
33
AI & Computing· Notable
Data-driven de novo design of super-adhesive hydrogels
E 94I 79N 59
46
34
AI & Computing· Notable
AI-enabled virtual spatial proteomics from histopathology for interpretable biomarker discovery in lung cancer
E 93I 74N 42
44
35
AI & Computing· Notable
A Robot Performs a Full Surgical Step on Lifelike Tissue Without Human Help
E 90I 94N 48
44
36
AI & Computing· Notable
AlphaEvolve breaks a 56-year-old matrix-multiplication record
E 68I 95N 53
41
37
AI & Computing· Notable
TabPFN Beats Decades of Tabular Machine Learning in Seconds
E 97I 98N 42
40
38
AI & Computing· Emerging
AMIE Matches Physicians at Diagnostic Conversation
E 97I 88N 40
39
39
AI & Computing· Emerging
Gemini Robotics brings a foundation model into physical control
E 69I 59N 59
37
Every score decomposes to its raw sources on the breakthrough page.last refreshed 2026-11-15How it is computed

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