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Neuroscience

Latest Neuroscience Breakthroughs

Brains and minds: neural circuits, cognition, and brain-computer interfaces. Every Neuroscience result in the index, its impact anchored on work of its own field and year, ranked by Frontier Score.

Top of the field · Notable

Aggression experience and observation drive shared behavioural and neural changes

Mice that only watched fights later fought more like experienced fighters, with shared brain changes

70/ 100

Evidence 93Impact 45Novelty 72

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Every Neuroscience breakthrough

Ranked by live Frontier Score. Search, filter by date, or sort by any pillar.

57 breakthroughs
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Since
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01
Neuroscience· Notable
Aggression experience and observation drive shared behavioural and neural changes
E 93I 45N 72
70
02
Neuroscience· Notable
An astrocyte-microglia MFG-E8 axis promotes synapse engulfment in early amyloid pathology
E 90I 48N 73
70
03
Neuroscience· Notable
Connectome simulations identify a central pattern generator for fly walking
E 96I 62N 65
70
04
Neuroscience· Notable
Functional architecture of the human insula
E 94I 50N 74
70
05
Neuroscience· Notable
Transcriptomic convergence and the female protective effect in autism
E 95I 59N 64
69
06
Neuroscience· Notable
Transcranial magnetic stimulation to the dorsolateral prefrontal cortex modulates single-neuron activity in humans
E 91I 44N 72
69
07
Neuroscience· Notable
Disruption of cell-type-specific molecular programs of striatal spiny projection neurons in autism
E 91I 63N 63
69
08
Neuroscience· Notable
A population code for semantics in human hippocampus
E 90I 58N 74
69
09
Neuroscience· Notable
Lifespan single-cell transcriptomic atlas of the human prefrontal cortex
E 96I 56N 72
69
10
Neuroscience· Major
Sexual dimorphism in the complete Drosophila male central nervous system connectome
E 97I 76N 67
69
11
Neuroscience· Notable
Information formatting in neuronal populations predicts differential functional contributions to behavior
E 93I 45N 69
68
12
Neuroscience· Notable
Intrinsic gestational timing governs human cerebellar development after preterm birth
E 91I 45N 70
68
13
Neuroscience· Notable
Emotion regulation capacity lacks a shared neural signature
E 94I 48N 68
68
14
Neuroscience· Notable
Identification of candidate markers for the isolation of neuron-specific extracellular vesicles
E 91I 53N 69
68
15
Neuroscience· Notable
What one sees depends on how far the eye has moved
E 89I 37N 88
68
16
Neuroscience· Notable
Perinatal elimination of genetically aberrant human cortical neurons
E 96I 35N 71
67
17
Neuroscience· Notable
Persistent neuronal stress signalling underlies Angelman syndrome phenotypes
E 94I 34N 73
66
18
Neuroscience· Notable
The lipidomic architecture of the mouse brain
E 94I 59N 66
66
19
Neuroscience· Notable
Ultrafast venous and sagittal sinus constrictions in the brain driven by abdominal pressure
E 93I 49N 71
66
20
Neuroscience· Major
Single-cell atlas of transcriptomic vulnerability across brain disorders
E 96I 51N 69
66
21
Neuroscience· Notable
Education reduces dementia incidence and mitigates genetic risk
E 93I 37N 69
65
22
Neuroscience· Notable
Targeted stimulation of motor cortex ensembles drives learned movements
E 94I 49N 64
65
23
Neuroscience· Notable
Single-nucleus transcriptome-wide association study of human brain disorders
E 96I 51N 66
65
24
Neuroscience· Notable
Loss of cerebral autoregulation drives abnormal perfusion patterns after stroke
E 91I 47N 67
64
25
Neuroscience· Notable
Single-nucleus atlas of cell-type specific genetic regulation in the human brain
E 93I 50N 65
64
26
Neuroscience· Notable
Heterochronicity shapes brain network formation
E 91I 36N 68
63
27
Neuroscience· Notable
Comprehensive profiling of brain dynamics during anesthesia across phylogeny
E 91I 49N 64
63
28
Neuroscience· Notable
An amygdala to anterior hypothalamic circuit gates stress sensitivity
E 94I 38N 66
62
29
Neuroscience· Major
Distributed control circuits across a brain-and-cord connectome
E 97I 75N 67
62
30
Neuroscience· Notable
Human claustrum neurons encode uncertainty and prediction errors during aversive learning
E 91I 35N 66
61
31
Neuroscience· Notable
Intracranial recordings in humans reveal differential contributions of medial and lateral orbitofrontal cortex to approach–avoidance decision-making
E 91I 44N 64
61
32
Neuroscience· Notable
Selfish and prosocial individuals both distort their actions’ impact, but selfish distortions can be more contagious
E 91I 31N 65
60
33
Neuroscience· Notable
Prion-like transmission of human tau strains in the mouse brain
E 96I 42N 59
60
34
Neuroscience· Notable
Functional brain networks underlying approach–avoidance conflict processing in humans and rats
E 91I 31N 65
59
35
Neuroscience· Notable
A cortical output channel for perceptual categorization
E 86I 59N 60
59
36
Neuroscience· Notable
Noninvasive decoding of typed sentences from human brain activity
E 91I 70N 60
59
37
Neuroscience· Notable
Shedding light on left hippocampal mGlu5 in Alzheimer’s disease
E 91I 0N 71
56
38
Neuroscience· Major
Neuropixels Opto: combining high-resolution electrophysiology and optogenetics
E 93I 60N 62
56
39
Neuroscience· Notable
Blinks are strategically coupled with head movements in unconstrained natural gaze behavior
E 91I 0N 67
55
40
Neuroscience· Notable
CX3CL1 (fractalkine)–CX3CR1 interface drives CD8⁺ T cell–induced neurodegeneration in human brain organoids
E 93I 0N 67
55
41
Neuroscience· Notable
System-level synchronization and subtype-specific modules govern brain-wide serotonin axon innervation
E 91I 0N 73
55
42
Neuroscience· Notable
Intraventricular clindamycin enhances interstitial brain fluid drainage and the blood–brain barrier after a traumatic brain injury
E 93I 0N 62
53
43
Neuroscience· Notable
Intrinsic rewards guide visual resource allocation via reinforcement learning
E 88I 0N 69
53
44
Neuroscience· Notable
Dynamic attribute activation explains gaze biases in choice
E 91I 0N 67
52
45
Neuroscience· Major
Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease
E 96I 73N 57
52
46
Neuroscience· Notable
Facial palsy reveals the sensorimotor contribution to facial-emotion recognition
E 91I 0N 63
50
47
Neuroscience· Notable
An axon-intrinsic loop restricts nerve regeneration through axonal protein synthesis
E 89I 0N 64
49
48
Neuroscience· Notable
Identifiability of Bayesian models of perception
E 91I 0N 58
48
49
Neuroscience· Notable
The glymphatic system clears amyloid beta and tau from brain to plasma in humans
E 89I 77N 49
48
50
Neuroscience· Notable
A Light-Powered Retinal Chip Restores Reading Vision in Advanced Macular Degeneration
E 99I 72N 54
47
Showing 50 of 57Show all 57
Every score decomposes to its raw sources on the breakthrough page.last refreshed 2026-11-14How it is computed

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