| 01 | Neuroscience· Notable Aggression experience and observation drive shared behavioural and neural changesMice that only watched fights later fought more like experienced fighters, with shared brain changes E 93I 45N 72 | 70 | 93 | 45 | 72 | Early signal | Nov 4, 2026 |
| 02 | Neuroscience· Notable An astrocyte-microglia MFG-E8 axis promotes synapse engulfment in early amyloid pathologyIn mice, astrocytes in an early bulbous state release a signal microglia need to eat the synapses beside them E 90I 48N 73 | 70 | 90 | 48 | 73 | Early signal | Nov 1, 2026 |
| 03 | Neuroscience· Notable Connectome simulations identify a central pattern generator for fly walkingE 96I 62N 65 | 70 | 96 | 62 | 65 | Early signal | Oct 28, 2026 |
| 04 | Neuroscience· Notable Functional architecture of the human insulaE 94I 50N 74 | 70 | 94 | 50 | 74 | Early signal | Oct 21, 2026 |
| 05 | Neuroscience· Notable Transcriptomic convergence and the female protective effect in autismSeparately knocking down 18 autism genes in lab-grown neural cells lowered many of the same other autism genes E 95I 59N 64 | 69 | 95 | 59 | 64 | Early signal | Nov 4, 2026 |
| 06 | Neuroscience· Notable Transcranial magnetic stimulation to the dorsolateral prefrontal cortex modulates single-neuron activity in humansIn four patients, single magnetic pulses to the prefrontal cortex changed firing in 46% of recorded neurons E 91I 44N 72 | 69 | 91 | 44 | 72 | Early signal | Nov 2, 2026 |
| 07 | Neuroscience· Notable Disruption of cell-type-specific molecular programs of striatal spiny projection neurons in autismE 91I 63N 63 | 69 | 91 | 63 | 63 | Early signal | Nov 1, 2026 |
| 08 | Neuroscience· Notable A population code for semantics in human hippocampusE 90I 58N 74 | 69 | 90 | 58 | 74 | Early signal | Sep 30, 2026 |
| 09 | Neuroscience· Notable Lifespan single-cell transcriptomic atlas of the human prefrontal cortexE 96I 56N 72 | 69 | 96 | 56 | 72 | Early signal | Sep 23, 2026 |
| 10 | Neuroscience· Major Sexual dimorphism in the complete Drosophila male central nervous system connectomeThe first complete male fruit fly nervous system, brain and nerve cord, at synaptic resolution E 97I 76N 67 | 69 | 97 | 76 | 67 | Firming up | Sep 1, 2026 |
| 11 | Neuroscience· Notable Information formatting in neuronal populations predicts differential functional contributions to behaviorTwo monkey brain areas format the same signals differently, and stimulating each changed choices differently E 93I 45N 69 | 68 | 93 | 45 | 69 | Early signal | Nov 10, 2026 |
| 12 | Neuroscience· Notable Intrinsic gestational timing governs human cerebellar development after preterm birthE 91I 45N 70 | 68 | 91 | 45 | 70 | Early signal | Oct 29, 2026 |
| 13 | Neuroscience· Notable Emotion regulation capacity lacks a shared neural signatureE 94I 48N 68 | 68 | 94 | 48 | 68 | Early signal | Oct 28, 2026 |
| 14 | Neuroscience· Notable Identification of candidate markers for the isolation of neuron-specific extracellular vesiclesA neuron surface protein, NRXN3, gives a handle for pulling candidate neuron vesicles from blood E 91I 53N 69 | 68 | 91 | 53 | 69 | Early signal | Oct 23, 2026 |
| 15 | Neuroscience· Notable What one sees depends on how far the eye has movedE 89I 37N 88 | 68 | 89 | 37 | 88 | Early signal | Aug 30, 2026 |
| 16 | Neuroscience· Notable Perinatal elimination of genetically aberrant human cortical neuronsE 96I 35N 71 | 67 | 96 | 35 | 71 | Early signal | Oct 28, 2026 |
| 17 | Neuroscience· Notable Persistent neuronal stress signalling underlies Angelman syndrome phenotypesE 94I 34N 73 | 66 | 94 | 34 | 73 | Early signal | Oct 21, 2026 |
| 18 | Neuroscience· Notable The lipidomic architecture of the mouse brainE 94I 59N 66 | 66 | 94 | 59 | 66 | Early signal | Sep 23, 2026 |
| 19 | Neuroscience· Notable Ultrafast venous and sagittal sinus constrictions in the brain driven by abdominal pressureE 93I 49N 71 | 66 | 93 | 49 | 71 | Early signal | Sep 23, 2026 |
| 20 | Neuroscience· Major Single-cell atlas of transcriptomic vulnerability across brain disordersE 96I 51N 69 | 66 | 96 | 51 | 69 | Firming up | Sep 23, 2026 |
| 21 | Neuroscience· Notable Education reduces dementia incidence and mitigates genetic riskE 93I 37N 69 | 65 | 93 | 37 | 69 | Early signal | Oct 23, 2026 |
| 22 | Neuroscience· Notable Targeted stimulation of motor cortex ensembles drives learned movementsE 94I 49N 64 | 65 | 94 | 49 | 64 | Early signal | Oct 14, 2026 |
| 23 | Neuroscience· Notable Single-nucleus transcriptome-wide association study of human brain disordersE 96I 51N 66 | 65 | 96 | 51 | 66 | Early signal | Sep 23, 2026 |
| 24 | Neuroscience· Notable Loss of cerebral autoregulation drives abnormal perfusion patterns after strokeE 91I 47N 67 | 64 | 91 | 47 | 67 | Early signal | Sep 29, 2026 |
| 25 | Neuroscience· Notable Single-nucleus atlas of cell-type specific genetic regulation in the human brainE 93I 50N 65 | 64 | 93 | 50 | 65 | Early signal | Sep 23, 2026 |
| 26 | Neuroscience· Notable Heterochronicity shapes brain network formationE 91I 36N 68 | 63 | 91 | 36 | 68 | Early signal | Oct 12, 2026 |
| 27 | Neuroscience· Notable Comprehensive profiling of brain dynamics during anesthesia across phylogenyE 91I 49N 64 | 63 | 91 | 49 | 64 | Early signal | Sep 29, 2026 |
| 28 | Neuroscience· Notable An amygdala to anterior hypothalamic circuit gates stress sensitivityE 94I 38N 66 | 62 | 94 | 38 | 66 | Early signal | Sep 30, 2026 |
| 29 | Neuroscience· Major Distributed control circuits across a brain-and-cord connectomeFirst adult fruit fly connectome joining brain and ventral nerve cord E 97I 75N 67 | 62 | 97 | 75 | 67 | Firming up | Jun 8, 2026 |
| 30 | Neuroscience· Notable Human claustrum neurons encode uncertainty and prediction errors during aversive learningE 91I 35N 66 | 61 | 91 | 35 | 66 | Early signal | Oct 6, 2026 |
| 31 | Neuroscience· Notable Intracranial recordings in humans reveal differential contributions of medial and lateral orbitofrontal cortex to approach–avoidance decision-makingE 91I 44N 64 | 61 | 91 | 44 | 64 | Early signal | Sep 15, 2026 |
| 32 | Neuroscience· Notable Selfish and prosocial individuals both distort their actions’ impact, but selfish distortions can be more contagiousE 91I 31N 65 | 60 | 91 | 31 | 65 | Early signal | Oct 1, 2026 |
| 33 | Neuroscience· Notable Prion-like transmission of human tau strains in the mouse brainE 96I 42N 59 | 60 | 96 | 42 | 59 | Early signal | Sep 30, 2026 |
| 34 | Neuroscience· Notable Functional brain networks underlying approach–avoidance conflict processing in humans and ratsE 91I 31N 65 | 59 | 91 | 31 | 65 | Early signal | Sep 29, 2026 |
| 35 | Neuroscience· Notable A cortical output channel for perceptual categorizationOnly one deep-layer cortical output cell type gains categorical responses as mice learn to categorize sounds E 86I 59N 60 | 59 | 86 | 59 | 60 | Early signal | Aug 26, 2026 |
| 36 | Neuroscience· Notable Noninvasive decoding of typed sentences from human brain activityA model reads typed sentences off magnetic recordings of the brain, with no implant E 91I 70N 60 | 59 | 91 | 70 | 60 | Early signal | Jun 29, 2026 |
| 37 | Neuroscience· Notable Shedding light on left hippocampal mGlu5 in Alzheimer’s diseaseE 91I 0N 71 | 56 | 91 | 0 | 71 | Early signal | Oct 12, 2026 |
| 38 | Neuroscience· Major Neuropixels Opto: combining high-resolution electrophysiology and optogeneticsNeuropixels probe fusing 960 recording sites with on-shank optogenetic light emitters E 93I 60N 62 | 56 | 93 | 60 | 62 | Firming up | Jun 1, 2026 |
| 39 | Neuroscience· Notable Blinks are strategically coupled with head movements in unconstrained natural gaze behaviorE 91I 0N 67 | 55 | 91 | 0 | 67 | Early signal | Oct 22, 2026 |
| 40 | Neuroscience· Notable CX3CL1 (fractalkine)–CX3CR1 interface drives CD8⁺ T cell–induced neurodegeneration in human brain organoidsE 93I 0N 67 | 55 | 93 | 0 | 67 | Early signal | Oct 20, 2026 |
| 41 | Neuroscience· Notable System-level synchronization and subtype-specific modules govern brain-wide serotonin axon innervationE 91I 0N 73 | 55 | 91 | 0 | 73 | Early signal | Sep 22, 2026 |
| 42 | Neuroscience· Notable Intraventricular clindamycin enhances interstitial brain fluid drainage and the blood–brain barrier after a traumatic brain injuryE 93I 0N 62 | 53 | 93 | 0 | 62 | Early signal | Oct 27, 2026 |
| 43 | Neuroscience· Notable Intrinsic rewards guide visual resource allocation via reinforcement learningE 88I 0N 69 | 53 | 88 | 0 | 69 | Early signal | Oct 1, 2026 |
| 44 | Neuroscience· Notable Dynamic attribute activation explains gaze biases in choiceE 91I 0N 67 | 52 | 91 | 0 | 67 | Early signal | Sep 25, 2026 |
| 45 | Neuroscience· Major Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s diseaseSingle-cell multiomic profiling maps hippocampal neurogenesis across ageing and Alzheimer's disease E 96I 73N 57 | 52 | 96 | 73 | 57 | Firming up | Feb 25, 2026 |
| 46 | Neuroscience· Notable Facial palsy reveals the sensorimotor contribution to facial-emotion recognitionE 91I 0N 63 | 50 | 91 | 0 | 63 | Early signal | Sep 11, 2026 |
| 47 | Neuroscience· Notable An axon-intrinsic loop restricts nerve regeneration through axonal protein synthesisA REG3A-to-KHSRP axonal loop brakes peripheral nerve regeneration through localized mRNA translation E 89I 0N 64 | 49 | 89 | 0 | 64 | Early signal | Aug 26, 2026 |
| 48 | Neuroscience· Notable Identifiability of Bayesian models of perceptionE 91I 0N 58 | 48 | 91 | 0 | 58 | Early signal | Sep 11, 2026 |
| 49 | Neuroscience· Notable The glymphatic system clears amyloid beta and tau from brain to plasma in humansNormal sleep raises plasma amyloid beta and tau versus sleep deprivation in a randomized crossover trial E 89I 77N 49 | 48 | 89 | 77 | 49 | Settled | Jan 27, 2026 |
| 50 | Neuroscience· Notable A Light-Powered Retinal Chip Restores Reading Vision in Advanced Macular DegenerationA subretinal photovoltaic implant plus infrared glasses gave most trial patients back central sight in a disease with no prior treatment. E 99I 72N 54 | 47 | 99 | 72 | 54 | Settled | Oct 20, 2025 |
| 51 | Neuroscience· Notable Reading Silent Inner Speech From the Motor Cortex, With a Privacy LockImagined sentences are decoded in real time, and a mental password stops the device from listening in. E 96I 77N 57 | 45 | 96 | 77 | 57 | Settled | Aug 1, 2025 |
| 52 | Neuroscience· Notable Centaur: a language model that predicts how people behaveOne fine-tuned model forecasts human choices across 160 psychology experiments. E 94I 88N 46 | 43 | 94 | 88 | 46 | Settled | Jul 2, 2025 |
| 53 | Neuroscience· Notable A Cubic Millimeter of Brain, Mapped in Structure and FunctionMICrONS fused live neural activity with a full wiring diagram of mouse visual cortex. E 97I 91N 45 | 41 | 97 | 91 | 45 | Settled | Apr 9, 2025 |
| 54 | Neuroscience· Notable Deep-Brain Stimulation Finds a Signal That Predicts Who Beats DepressionAn intracranial biomarker forecasts response to BNST-NAc stimulation for treatment-refractory depression. E 89I 56N 46 | 40 | 89 | 56 | 46 | Firming up | Nov 18, 2025 |
| 55 | Neuroscience· Emerging A Foundation Model of the Visual Brain That Transfers Across MiceOne pretrained model predicts cortical responses to stimuli it never saw, and even reads out cell types and wiring. E 91I 77N 47 | 39 | 91 | 77 | 47 | Settled | Apr 9, 2025 |
| 56 | Neuroscience· Emerging A General Wiring Rule of the Cortex, Read From a Millimeter of Mouse BrainIn the MICrONS connectome, neurons that respond alike are preferentially wired together, and so are trained neural networks. E 96I 74N 43 | 38 | 96 | 74 | 43 | Settled | Apr 9, 2025 |
| 57 | Neuroscience· Emerging Neuronal wiring diagram of an adult brainThe first complete wiring diagram of an adult fruit fly brain E 97I 88N 39 | 37 | 97 | 88 | 39 | Settled | Oct 2, 2024 |